Sherman M I, Shalgi R, Rizzino A, Sellens M H, Gay S, Gay R
Ciba Found Symp. 1978(64):33-52. doi: 10.1002/9780470720479.ch3.
Implantation is a critical event, and perhaps the earliest one, in the maternal recognition of pregnancy. Information transfer from conceptus to mother might occur during, and subsequent to, implantation at the level of cell surface interaction. Therefore, attempts have been made both to identify the phases of implantation during which changes in the blastocyst surface occur and to characterized such changes. In vitro, blastocysts have been found to go through a series of discrete steps which are analogous to implantation in utero, and these steps can be retarded or prevented by the use of either suboptimal culture media or an inappropriate substratum. Morphological surface changes are not apparent when the blastocyst becomes adherent to the substratum; however, marked differences in blastocyst surface structure are revealed by scanning electron microscopy at the onset of trophoblast outgrowth. Studies at the molecular level implicate collagen as having a role in blastocyst adhesiveness, but other cell surface components are also likely to be involved.
着床是母体识别妊娠过程中的一个关键事件，或许也是最早的事件。在着床期间及之后，在细胞表面相互作用层面可能会发生从受精卵到母体的信息传递。因此，人们既尝试确定囊胚表面发生变化的着床阶段，也尝试对这些变化进行表征。在体外，已发现囊胚会经历一系列与子宫内着床类似的离散步骤，使用次优培养基或不合适的基质会使这些步骤延迟或受阻。当囊胚附着于基质时，形态学表面变化并不明显；然而，在滋养层生长开始时，扫描电子显微镜揭示了囊胚表面结构的显著差异。分子水平的研究表明胶原蛋白在囊胚黏附中起作用，但其他细胞表面成分可能也参与其中。
