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Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis.

作者信息

Crouch Peter J

机构信息

From the Department of Pathology and Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.

出版信息

Neurology. 2015 May 19;84(20):2038. doi: 10.1212/WNL.0000000000001600. Epub 2015 Apr 22.

DOI:10.1212/WNL.0000000000001600
PMID:25904689
Abstract
摘要

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PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction.正电子发射断层扫描(PET)成像在与线粒体功能障碍相关的神经退行性疾病中用于检测氧化应激
Antioxidants (Basel). 2020 Sep 14;9(9):861. doi: 10.3390/antiox9090861.
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CuATSM efficacy is independently replicated in a SOD1 mouse model of ALS while unmetallated ATSM therapy fails to reveal benefits.在肌萎缩侧索硬化症的超氧化物歧化酶1(SOD1)小鼠模型中,铜-阿替生(CuATSM)的疗效得到了独立验证,而未金属化的阿替生(ATSM)治疗则未显示出益处。
IBRO Rep. 2017 Mar 12;2:47-53. doi: 10.1016/j.ibror.2017.03.001. eCollection 2017 Jun.