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减压病的延迟再压缩:回顾性分析

Delayed recompression for decompression sickness: retrospective analysis.

作者信息

Hadanny Amir, Fishlev Gregori, Bechor Yair, Bergan Jacob, Friedman Mony, Maliar Amit, Efrati Shai

机构信息

The Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

The Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel.

出版信息

PLoS One. 2015 Apr 23;10(4):e0124919. doi: 10.1371/journal.pone.0124919. eCollection 2015.

Abstract

INTRODUCTION

Most cases of decompression sickness (DCS) occur soon after surfacing, with 98% within 24 hours. Recompression using hyperbaric chamber should be administrated as soon as feasible in order to decrease bubble size and avoid further tissue injury. Unfortunately, there may be a significant time delay from surfacing to recompression. The time beyond which hyperbaric treatment is non effective is unclear. The aims of the study were first to evaluate the effect of delayed hyperbaric treatment, initiated more than 48 h after surfacing for DCS and second, to evaluate the different treatment protocols.

METHODS

From January 2000 to February 2014, 76 divers had delayed hyperbaric treatment (≥48 h) for DCS in the Sagol center for Hyperbaric medicine and Research, Assaf-Harofeh Medical Center, Israel. Data were collected from their medical records and compared to data of 128 patients treated earlier than 48 h after surfacing at the same hyperbaric institute.

RESULTS

There was no significant difference, as to any of the baseline characteristics, between the delayed and early treatment groups. With respect to treatment results, at the delayed treatment divers, complete recovery was achieved in 76% of the divers, partial recovery in 17.1% and no improvement in 6.6%. Similar results were achieved when treatment started early, where 78% of the divers had complete recovery, 15.6% partial recovery and 6.2% no recovery. Delayed hyperbaric treatment using US Navy Table 6 protocol trended toward a better clinical outcome yet not statistically significant (OR=2.786, CI95%[0.896-8.66], p=0.07) compared to standard hyperbaric oxygen therapy of 90 minutes at 2 ATA, irrespective of the symptoms severity at presentation.

CONCLUSIONS

Late recompression for DCS, 48 hours or more after surfacing, has clinical value and when applied can achieve complete recovery in 76% of the divers. It seems that the preferred hyperbaric treatment protocol should be based on US Navy Table 6.

摘要

引言

大多数减压病(DCS)病例在浮出水面后不久就会出现,98%的病例在24小时内。应尽快使用高压舱进行再加压,以减小气泡大小并避免进一步的组织损伤。不幸的是,从浮出水面到再加压可能会有显著的时间延迟。高压治疗无效的时间尚不清楚。本研究的目的首先是评估在浮出水面48小时后开始的延迟高压治疗对DCS的效果,其次是评估不同的治疗方案。

方法

2000年1月至2014年2月,76名潜水员在以色列阿萨夫-哈罗费医疗中心萨戈尔高压医学与研究中心接受了针对DCS的延迟高压治疗(≥48小时)。从他们的病历中收集数据,并与在同一高压治疗机构浮出水面后48小时内接受治疗的128名患者的数据进行比较。

结果

延迟治疗组和早期治疗组在任何基线特征方面均无显著差异。关于治疗结果,延迟治疗的潜水员中,76%完全康复,17.1%部分康复,6.6%无改善。早期开始治疗时也取得了类似的结果,78%的潜水员完全康复,15.6%部分康复,6.2%未康复。与2个绝对大气压下90分钟的标准高压氧治疗相比,无论初始症状严重程度如何,使用美国海军表6方案进行延迟高压治疗的临床结果有更好的趋势,但无统计学意义(OR = 2.786,95%CI[0.896 - 8.66],p = 0.07)。

结论

浮出水面48小时或更长时间后对DCS进行延迟再加压具有临床价值,应用时76%的潜水员可实现完全康复。似乎首选的高压治疗方案应基于美国海军表6。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf5a/4408070/f1835f0f80d5/pone.0124919.g001.jpg

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