Blumenfeld Britny, Ben-Zimra Micha, Simon Itamar
Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Pharmacology and Experimental Therapeutics Unit, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Int J Mol Sci. 2017 May 25;18(6):1138. doi: 10.3390/ijms18061138.
Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
癌症和基因组不稳定性受到脱氧核糖核酸（DNA）复制程序的高度影响。DNA复制过程中的错误会导致突变和结构变异的增加。这些错误主要源于复制应激导致的DNA保真度丧失，或源于复制过程时间组织上的异常。在此，我们综述这些主要错误来源对复制程序的机制及影响。
