Dereci Selim, Pirgon Ozgur, Akcam Mustafa, Turkyilmaz Kemal, Dundar Bumin
Department of Pediatrics, S. Demirel University, Faculty of Medicine, Isparta - Turkey.
Department of Ophthalmology, R.T. Erdogan University, Faculty of Medicine, Rize - Turkey.
Eur J Ophthalmol. 2015 Nov-Dec;25(6):535-8. doi: 10.5301/ejo.5000587. Epub 2015 Apr 10.
Corticosteroids are under suspicion of playing an important role in the development of retinopathy. We aimed to determine peripapillary retinal nerve fiber layer (RNFL) thinning by spectral-domain optical coherence tomography (OCT) in children being treated with inhaled fluticasone propionate due to asthma.
Thirty-eight children diagnosed with allergic asthma (mean age 9.8 ± 2.8 years, age range 6-13 years) and 40 age-similar controls were enrolled in this study. All children with asthma were taking inhaled fluticasone propionate at a dosage of 250 µg or more per day for at least 1 year. The RNFL thickness measurements were performed using Cirrus HD spectral-domain OCT 400. Central subfield thickness, cube average thickness, and cube volume were also measured.
Among the 38 children with asthma and 40 healthy subjects who completed follow-up, children with asthma had similar mean peripapillary RNFL thicknesses compared with control children. The mean central subfield thickness was significantly higher than that of controls (248.8 ± 23.4 vs 237.5 ± 23.5, p<0.037). There was a positive linear relationship between cube average thickness and eosinophil count with a Pearson correlation coefficient of 0.336 (p<0.039) and a negative correlation was found between central subfield thickness and disease duration (r = -0.385, p = 0.017) in children with asthma.
Asthmatic children have similar peripapillary RNFL measurements compared to controls on spectral-domain OCT. Raised eosinophil counts in asthmatic children were found to be significantly associated with cube average thickness.
皮质类固醇被怀疑在视网膜病变的发展中起重要作用。我们旨在通过光谱域光学相干断层扫描（OCT）确定因哮喘接受吸入丙酸氟替卡松治疗的儿童的视乳头周围视网膜神经纤维层（RNFL）变薄情况。
本研究纳入了38名诊断为过敏性哮喘的儿童（平均年龄9.8±2.8岁，年龄范围6 - 13岁）和40名年龄相仿的对照儿童。所有哮喘儿童每天服用剂量为250μg或更高的吸入丙酸氟替卡松至少1年。使用Cirrus HD光谱域OCT 400进行RNFL厚度测量。还测量了中央子区域厚度、立方体平均厚度和立方体体积。
在完成随访的38名哮喘儿童和40名健康受试者中，哮喘儿童的平均视乳头周围RNFL厚度与对照儿童相似。平均中央子区域厚度显著高于对照组（248.8±23.4 vs 237.5±23.5，p<0.037）。哮喘儿童的立方体平均厚度与嗜酸性粒细胞计数之间存在正线性关系，Pearson相关系数为0.336（p<0.039），并且中央子区域厚度与疾病持续时间之间存在负相关（r = -0.385，p = 0.017）。
在光谱域OCT上，哮喘儿童的视乳头周围RNFL测量值与对照组相似。发现哮喘儿童中嗜酸性粒细胞计数升高与立方体平均厚度显著相关。
