Gunay Murat, Dogru Mahmut, Celik Gokhan, Gunay Betul Onal
a Department of Ophthalmology , Trabzon Fatih State Hospital , Trabzon , Turkey.
b Department of Pediatric Allergy and Immunology , Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital , İstanbul , Turkey.
Cutan Ocul Toxicol. 2019 Jun;38(2):131-135. doi: 10.1080/15569527.2018.1539009. Epub 2018 Nov 23.
To evaluate retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT) in asthmatic children who were under inhaled corticosteroid treatment by using Swept-Source Optical Coherence Tomography (SS-OCT).
Fifty-three children were prospectively analyzed in the study. Group 1 included 31 asthmatic children and group 2 included 22 healthy children. Asthmatic children received a dose 250 μg daily of inhaled fluticasone propionate (Flexotide, GlaxoSmithKline, Middlesex, UK). Allergy parameters including, exposure to smoke, eosinophil count, percentage of eosinophils, immunoglobuline (Ig) E levels, number of asthma attacks, number of sensitivity to allergens and follow-up time were recorded. The RNFLT, GCLT, SFCT, and CRT were analyzed with SS-OCT and the data were compared between the groups.
There were 13 girls (41.9%) and 18 boys (58.1%) in group 1 and 13 girls (59.1%) and 9 boys (40.9%) in group 2 (p = 0.22). The mean age was 9.3 ± 2.2 years in group 1 and 9.9 ± 1.5 years in group 2 (p = 0.08). The mean CRT (239.26 ± 34.56 µm versus 226.82 ± 26.23 µm, p = 0.22) and mean SFCT (273.97 ± 40.95 µm versus 280.41 ± 32.78 µm, p = 0.54) did not significantly differ between the groups. The superior, inferior, and average RNFLT were significantly lower in group 1 than group 2 (p < 0.05). There were significant correlations between total corticosteroid dose and RNFLT (p < 0.05) and between IgE levels and GCLT (p < 0.05).
The SS-OCT revealed that asthmatic children under inhaled corticosteroid treatment have lower RNFLT than healthy subjects.
采用扫频光学相干断层扫描（SS-OCT）评估接受吸入性糖皮质激素治疗的哮喘儿童的视网膜神经纤维层厚度（RNFLT）、神经节细胞层厚度（GCLT）、黄斑中心凹下脉络膜厚度（SFCT）和中央视网膜厚度（CRT）。
本研究前瞻性分析了53名儿童。第1组包括31名哮喘儿童，第2组包括22名健康儿童。哮喘儿童每日接受250μg吸入性丙酸氟替卡松（辅舒酮，葛兰素史克公司，英国米德尔塞克斯）治疗。记录过敏参数，包括接触烟雾情况、嗜酸性粒细胞计数、嗜酸性粒细胞百分比、免疫球蛋白（Ig）E水平、哮喘发作次数、过敏原敏感性次数和随访时间。用SS-OCT分析RNFLT、GCLT、SFCT和CRT，并对两组数据进行比较。
第1组有13名女孩（41.9%）和18名男孩（58.1%），第2组有13名女孩（59.1%）和9名男孩（40.9%）（p = 0.22）。第1组平均年龄为9.3±2.2岁，第2组平均年龄为9.9±1.5岁（p = 0.08）。两组间平均CRT（239.26±34.56μm对226.82±26.23μm，p = 0.22）和平均SFCT（273.97±40.95μm对280.41±32.78μm，p = 0.54）无显著差异。第1组的上方、下方和平均RNFLT显著低于第2组（p < 0.05）。总糖皮质激素剂量与RNFLT之间（p < 0.05）以及IgE水平与GCLT之间（p < 0.05）存在显著相关性。
SS-OCT显示，接受吸入性糖皮质激素治疗的哮喘儿童的RNFLT低于健康受试者。
