医院相关微生物组及其与医院感染的关系。

Hospital-associated microbiota and implications for nosocomial infections.

机构信息

Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA; Institute for Genomics and Systems Biology, Biosciences Department, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA; Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA; College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

出版信息

Trends Mol Med. 2015 Jul;21(7):427-32. doi: 10.1016/j.molmed.2015.03.005. Epub 2015 Apr 20.

DOI:10.1016/j.molmed.2015.03.005

PMID:25907678

Abstract

The rise of high-throughput sequencing technologies and culture-independent microbial surveys has the potential to revolutionize our understanding of how microbes colonize, move about, and evolve in hospital environments. Genome analysis of individual organisms, characterization of population dynamics, and microbial community ecology are facilitating the identification of novel pathogens, the tracking of disease outbreaks, and the study of the evolution of antibiotic resistance. Here we review the recent applications of these methods to microbial ecology studies in hospitals and discuss their potential to influence hospital management policy and practice and to reduce nosocomial infections and the spread of antibiotic resistance.

摘要

高通量测序技术和非培养微生物调查的兴起有可能彻底改变我们对微生物在医院环境中定植、迁移和进化的方式的理解。对单个生物体的基因组分析、种群动态的特征描述和微生物群落生态学正在促进新病原体的鉴定、疾病暴发的跟踪以及抗生素耐药性进化的研究。在这里，我们回顾了这些方法在医院微生物生态学研究中的最新应用，并讨论了它们影响医院管理政策和实践以及减少医院感染和抗生素耐药性传播的潜力。