MacDonald H L, Best J J
Eastern General Hospital, Edinburgh.
Br J Psychiatry. 1989 Apr;154:492-8. doi: 10.1192/bjp.154.4.492.
This is the initial report of a prospective study by computerised tomography brain scan of first episode schizophrenia. Twenty-seven patients who met Research Diagnostic Criteria for schizophrenia were compared with volunteer controls on ventricular:brain ratio, sulcal:brain volume ratio, and the widths of third ventricle and Sylvian and interhemispheric fissures. The results provide evidence that sulcal enlargement, but not ventricular abnormalities, may be detected at first admission for schizophrenic illness, and are discussed in relation to findings from other studies.
这是一项关于首发精神分裂症患者脑部计算机断层扫描前瞻性研究的初步报告。将27名符合精神分裂症研究诊断标准的患者与志愿者对照在脑室与脑体积比、脑沟与脑体积比以及第三脑室、外侧裂和大脑半球间裂宽度方面进行了比较。结果表明，在精神分裂症首次入院时可能检测到脑沟增宽，而非脑室异常，并结合其他研究结果进行了讨论。
