线粒体医学在毒理学中毒方面的潜在应用。
The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning.
作者信息
Jang David H, Lampe Joshua W, Becker Lance B
机构信息
Center for Resuscitation Science and Center for Mitochondrial and Epigenomic Medicine, Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA,
出版信息
J Med Toxicol. 2015 Jun;11(2):201-7. doi: 10.1007/s13181-015-0478-8.
The advancement of biomolecular techniques has continued to advance in the area of mitochondrial medicine. This has allowed clinicians and researchers to more effectively study the bioenergetics of the mitochondria in various disease states. One potential technique in mitochondrial medicine is the generation of cytoplasmic hybrids. A cytoplasmic hybrid or cybrid are created by introducing mitochondrial DNA (mtDNA) of interest into cells depleted of mtDNA. A cybrid is therefore a hybrid cell that mixes the nuclear genome from one cell with the mitochondrial genes from another cell. Cybrids are currently utilized in mitochondrial research to demonstrate mitochondrial involvement in a wide range of diseases that include diabetes, Parkinson's disease and inherited diseases. At this time the use of cybrids to study toxicologic poisoning is limited and offers a potential avenue of research in this area.
生物分子技术在线粒体医学领域不断取得进展。这使临床医生和研究人员能够更有效地研究各种疾病状态下线粒体的生物能量学。线粒体医学中的一种潜在技术是细胞质杂种的产生。通过将感兴趣的线粒体DNA（mtDNA）导入去除mtDNA的细胞中来创建细胞质杂种或细胞杂种。因此，细胞杂种是一种将一个细胞的核基因组与另一个细胞的线粒体基因混合的杂种细胞。目前，细胞杂种被用于线粒体研究，以证明线粒体与包括糖尿病、帕金森病和遗传性疾病在内的多种疾病有关。目前，利用细胞杂种研究毒理学中毒的情况有限，为该领域提供了一个潜在的研究途径。
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