Cheng Jingyi, Sun Xinghuai
Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. Email:
Zhonghua Yan Ke Za Zhi. 2015 Feb;51(2):103-8.
To study the distribution of peak intraocular pressure (IOP) in 24-hour in untreated primary open angle glaucoma (POAG) patients, and to explore the correlation between nocturnal peak IOP and office hour or diurnal IOP level.
A Cross-sectional study.One hundred and twenty-one untreated POAG patients (121 eyes), including 78 normal tension patients (78 eyes) and 43 hyper-tension patients (43 eyes), were enrolled in this study. All the patients underwent 24-hour IOP monitoring with non-contact tonometer. The distribution of peak IOP in 24-hour and the correlation between nocturnal peak IOP and office hour or diurnal mean and peak IOP were evaluated. Categorical variables were described as frequency and constituent ratio, and analyzed by chi-square test. Continuous variables were described as mean, standard deviation, range, and analyzed by independent samples t test, pearson correlation test and linear regression.
In all glaucoma patients, peak IOP occurred mainly from 8:00 to 10:00 and 8:00 to 10:00.In normal tension group, peak IOP appeared mainly from 8:00 to 10:00 and from 0:00 to 6:00, the highest frequency showed at 8:00 (17 eyes 18.48%).In hyper-tension group, the probability of IOP reaching peak was more in night time, mainly from 0:00 to 6:00, the highest frequency showed at 2:00 (10 eyes 21.28%). If only the peak IOP during office hours or diurnal hours were considered, then only 32.55% (14/43) and 44.19% (19/43) patients could be correctly diagnosed. The remaining patients would be missed because of low IOP and/or mild structure and/or functional damages. There were good linear correlations between office hours or diurnal peak and mean IOP and nocturnal peak IOP in glaucoma patients.
More than 50% peak IOP occurred out of office hour in POAG patients. There is a good correlation between peak nocturnal IOP and office hour or diurnal IOP level.
研究未经治疗的原发性开角型青光眼（POAG）患者24小时眼压峰值的分布情况，并探讨夜间眼压峰值与门诊眼压或日间眼压水平之间的相关性。
一项横断面研究。纳入121例未经治疗的POAG患者（121只眼），其中78例正常眼压患者（78只眼）和43例高眼压患者（43只眼）。所有患者均使用非接触眼压计进行24小时眼压监测。评估24小时眼压峰值的分布情况以及夜间眼压峰值与门诊眼压或日间平均眼压及眼压峰值之间的相关性。分类变量以频率和构成比描述，并采用卡方检验进行分析。连续变量以均值、标准差、范围描述，并采用独立样本t检验、Pearson相关检验和线性回归进行分析。
在所有青光眼患者中，眼压峰值主要出现在8:00至10:00和0:00至6:00。在正常眼压组中，眼压峰值主要出现在8:00至10:00和0:00至6:00，最高频率出现在8:00（17只眼，18.48%）。在高眼压组中，眼压达到峰值的概率在夜间更高，主要在0:00至6:00，最高频率出现在2:00（10只眼，21.28%）。如果仅考虑门诊时间或日间的眼压峰值，那么仅有32.55%（14/43）和44.19%（19/43）的患者能够被正确诊断。其余患者会因眼压低和/或轻度结构和/或功能损害而漏诊。青光眼患者门诊时间或日间眼压峰值及平均眼压与夜间眼压峰值之间存在良好的线性相关性。
POAG患者超过50%的眼压峰值出现在门诊时间之外。夜间眼压峰值与门诊眼压或日间眼压水平之间存在良好的相关性。
