Veterans Affairs Medical Center, Jackson, Mississippi.
Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi.
J Med Virol. 2015 Aug;87(8):1377-81. doi: 10.1002/jmv.24195. Epub 2015 Apr 23.
Epidemiologic links between chronic hepatitis C and herpes simplex type-2 infection have been suggested; however, type-specific tests for HSV-2 infection have not been validated in patients with chronic hepatitis C infection. The Focus HerpeSelect(®) HSV-2 IgG (Cypress, California) assay and the Biokit HSV-2 rapid assay (Biokit USA, Lexington, MA) were performed on serum samples obtained from 84 veterans with chronic hepatitis C who demonstrated a previously positive HSV-2 serologic test in their medical records. Using the Biokit HSV-2 as the comparator assay, the positive predictive value, and specificity for the HerpeSelect(®) HSV-2 assay were 62.1% (95%CI: 49.3-73.8) and 41.9% (95%CI: 27.0-57.9), respectively. Increasing the HerpeSelect(®) HSV-2 index value defining a positive test result from >1.1 to ≥2.89 increased the assay's specificity to 97.7% (95%CI: 87.7-99.6) and the positive predictive value to 94.1%(95%CI: 71.2-99.0). J. Med. Virol. 9999: 1-5, 2015. © 2015 Wiley Periodicals, Inc. In veterans with chronic hepatitis C infection, HerpeSelect(®) HSV-2 index values between 1.1 and 2.89 should be confirmed with an alternate test for HSV-2 infection.
慢性丙型肝炎与单纯疱疹病毒 2 型感染之间存在流行病学联系；然而，针对 HSV-2 感染的特定类型检测并未在慢性丙型肝炎感染患者中得到验证。在来自 84 名慢性丙型肝炎退伍军人的血清样本中进行了 Focus HerpeSelect®HSV-2 IgG（加利福尼亚州 Cypress）检测和 Biokit HSV-2 快速检测（Biokit USA，马萨诸塞州列克星敦），这些患者的病历中先前有 HSV-2 血清学检测阳性。使用 Biokit HSV-2 作为比较检测，HerpeSelect®HSV-2 检测的阳性预测值和特异性分别为 62.1%（95%CI：49.3-73.8）和 41.9%（95%CI：27.0-57.9）。将 HerpeSelect®HSV-2 定义阳性检测结果的索引值从>1.1 增加到≥2.89，可将检测的特异性提高到 97.7%（95%CI：87.7-99.6），阳性预测值提高到 94.1%（95%CI：71.2-99.0）。J. Med. Virol. 9999：1-5，2015。©2015 Wiley Periodicals，Inc. 在慢性丙型肝炎感染的退伍军人中，HerpeSelect®HSV-2 索引值在 1.1 到 2.89 之间的应使用替代 HSV-2 感染检测方法进行确认。
