Wang Wei, Li Ping, Chen Yifei, Yang Jiong
Dept. of Respiratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei 430071, China.
Iran J Public Health. 2014 Jul;43(7):877-88.
The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.
The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.
Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.
This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.
许多已发表的研究探讨了β2-肾上腺素能受体（ADRB2）-16Arg/Gly多态性（rs1042713）与慢性阻塞性肺疾病（COPD）风险之间的关联。然而，结果尚无定论。进行了一项荟萃分析以更精确地估计两者之间的关系。
检索了PubMed、EMBASE、科学网ISI、Cochrane系统评价数据库以及中文数据库（中国知网、万方数据、中国生物医学文献数据库、维普资讯）中的已发表文献。采用比值比（OR）及95%置信区间（CI）评估关联强度。
荟萃分析纳入了11项研究，共1128例COPD患者和1182例对照。总体而言，在一般人群中，ADRB2 - 16Arg/Gly多态性与COPD风险之间无显著关联。在按潜在混杂变量进行的分层分析中，在显性遗传模型和等位基因模型（Arg vs. Gly）下，吸烟亚洲人群中ADRB2 - 16Arg/Gly多态性与COPD风险之间存在显著关联（显性模型：OR = 1.45，95%CI = 1.04 - 2.01，异质性P = 0.311，OR的z = 2.22，P = 0.026；等位基因模型：OR = 1.27，95%CI = 1.03 - 1.57，异质性P = 0.209，OR的z = 2.20，P = 0.028），但在其他亚组中未观察到。
这项荟萃分析表明，ADRB2 - 16Arg/Gly多态性可能是吸烟亚洲人群发生COPD的潜在危险因素，但在欧洲后裔中并非如此，吸烟可能增加了遗传易感性。需要更多大样本研究来验证该结果。
