Yoo Kwangsun, Chung Sun Ju, Kim Ho Sung, Choung Oh-Hyeon, Lee Young-Beom, Kim Mi-Jung, You Sooyeoun, Jeong Yong
Laboratory for Cognitive Neuroscience and NeuroImaging, Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea.
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
PLoS One. 2015 Apr 24;10(4):e0125455. doi: 10.1371/journal.pone.0125455. eCollection 2015.
Recently, non-motor symptoms of Parkinson's disease (PD) have been considered crucial factors in determining a patient's quality of life and have been proposed as the predominant features of the premotor phase. Researchers have investigated the relationship between non-motor symptoms and the motor laterality; however, this relationship remains disputed. This study investigated the neural connectivity correlates of non-motor and motor symptoms of PD with respect to motor laterality.
Eight-seven patients with PD were recruited and classified into left-more-affected PD (n = 44) and right-more affected PD (n = 37) based on their MDS-UPDRS (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale) motor examination scores. The patients underwent MRI scanning, which included resting fMRI. Brain regions were labeled as ipsilateral and contralateral to the more-affected body side. Correlation analysis between the functional connectivity across brain regions and the scores of various symptoms was performed to identify the neural connectivity correlates of each symptom.
The resting functional connectivity centered on the ipsilateral inferior orbito-frontal area was negatively correlated with the severity of non-motor symptoms, and the connectivity of the contralateral inferior parietal area was positively correlated with the severity of motor symptoms (p < 0.001, |r| > 0.3).
These results suggest that the inferior orbito-frontal area may play a crucial role in non-motor dysfunctions, and that the connectivity information may be utilized as a neuroimaging biomarker for the early diagnosis of PD.
近年来，帕金森病（PD）的非运动症状被认为是决定患者生活质量的关键因素，并被提出是运动前期的主要特征。研究人员已经调查了非运动症状与运动偏侧性之间的关系；然而，这种关系仍存在争议。本研究调查了PD的非运动和运动症状与运动偏侧性相关的神经连接。
招募了87例PD患者，并根据他们的MDS-UPDRS（运动障碍协会赞助的统一帕金森病评定量表修订版）运动检查评分分为左侧受累更严重的PD患者（n = 44）和右侧受累更严重的PD患者（n = 37）。患者接受了MRI扫描，其中包括静息态功能磁共振成像。脑区被标记为受累更严重身体侧的同侧和对侧。对脑区之间的功能连接与各种症状评分进行相关性分析，以确定每种症状的神经连接相关性。
以同侧眶额下回为中心的静息态功能连接与非运动症状的严重程度呈负相关，对侧顶下小叶的连接与运动症状的严重程度呈正相关（p < 0.001，|r| > 0.3）。
这些结果表明，眶额下回可能在非运动功能障碍中起关键作用，并且连接信息可作为PD早期诊断的神经影像学生物标志物。
