Yu Wuyang, Rahimi Rahim, Ochoa Manuel, Pinal Rodolfo, Ziaie Babak
IEEE Trans Biomed Eng. 2015 Sep;62(9):2289-95. doi: 10.1109/TBME.2015.2418340. Epub 2015 Apr 20.
In this paper, we present a smart capsule for location-specific drug release in the gastrointestinal tract. Once activated through a magnetic proximity fuse, the capsule opens up and releases its powdered payload in a location specified by an implanted miniature magnetic marker or an externally worn larger magnet. The capsule (9 mm × 26 mm) comprises of two compartments: one contains a charged capacitor and a reed switch, while the second one houses the drug reservoir capped by a taut nylon thread intertwined with a nichrome wire. The nichrome wire is connected to the capacitor through the reed switch. The capacitor is charged to 2.7 V before ingestion and once within the proximity of the permanent magnet; the reed switch closes, discharging the capacitor through the nichrome wire, melting the nylon thread, detaching the cap, and emptying the drug reservoir.
在本文中，我们展示了一种用于胃肠道特定位置药物释放的智能胶囊。一旦通过磁近程引信激活，胶囊就会打开，并在由植入的微型磁性标记物或外部佩戴的较大磁铁指定的位置释放其粉末状药物。该胶囊（9毫米×26毫米）由两个隔室组成：一个隔室包含一个充电电容器和一个簧片开关，而另一个隔室容纳药物储存器，该储存器由与镍铬合金线缠绕在一起的拉紧尼龙线封顶。镍铬合金线通过簧片开关连接到电容器。在摄入前，电容器充电至2.7V，一旦处于永久磁铁附近，簧片开关闭合，电容器通过镍铬合金线放电，熔化尼龙线，取下盖子，并清空药物储存器。
