Thorpe Samuel G, Cannon Erin N, Fox Nathan A
University of Maryland Child Development Laboratory, 3304 Benjamin Building, College Park, MD, USA.
Clin Neurophysiol. 2016 Jan;127(1):254-269. doi: 10.1016/j.clinph.2015.03.004. Epub 2015 Mar 20.
To assess the developmental trajectory of spectral, topographic, and source structural properties of functional mu desynchronization (characterized during voluntary reaching/grasping movement), and investigate its spectral/topographic relation to spontaneous EEG in the developing alpha band.
Event related desynchronization (ERD) and power spectral density spectra/topography are analyzed in 12 month-old infants, 4 year-old children, and adults. Age-matched head models derived from structural MRI are used to obtain current density reconstructions of mu desynchronization across the cortical surface.
Infant/child EEG contains spectral peaks evident in both the upper and lower developing alpha band, and spectral/topographic properties of functionally identified mu rhythm strongly reflect those of upper alpha in all subject groups. Source reconstructions show distributed frontoparietal patterns of cortical mu desynchronization concentrated in specific central and parietal regions which are consistent across age groups.
Peak frequencies of mu desynchronization and spontaneous alpha band EEG increase with age, and characteristic mu topography/source-structure is evident in development at least as early as 12 months.
Results provide evidence for a cortically distributed functional mu network, with spontaneous activity measurable in the upper alpha band throughout development.
评估功能性μ波去同步化（在自愿伸手/抓握运动中表现出特征）的频谱、地形图和源结构特性的发育轨迹，并研究其在发育中的α波段与自发脑电图的频谱/地形图关系。
对12个月大的婴儿、4岁儿童和成年人进行事件相关去同步化（ERD）以及功率谱密度谱/地形图分析。使用从结构磁共振成像（MRI）得出的年龄匹配头部模型，获取整个皮质表面μ波去同步化的电流密度重建。
婴儿/儿童脑电图在发育中的α波段上下均有明显的频谱峰值，功能识别的μ节律的频谱/地形图特性在所有受试者组中都强烈反映了上部α波的特性。源重建显示皮质μ波去同步化的额顶叶分布模式集中在特定的中央和顶叶区域，且各年龄组一致。
μ波去同步化和自发α波段脑电图的峰值频率随年龄增加，至少早在12个月大时，特征性的μ地形图/源结构在发育中就很明显。
结果为皮质分布的功能性μ网络提供了证据，在整个发育过程中，在上部α波段可测量到自发活动。
