Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.
Department of Public Health, Federico II University, Naples, Italy.
Eur J Neurol. 2015 Aug;22(8):1176-83. doi: 10.1111/ene.12720. Epub 2015 Apr 27.
Cardiovascular risk factors can increase the risk of multiple sclerosis (MS) and modify its course. However, such factors possibly interact, determining a global cardiovascular risk. Our aim was to compare the global cardiovascular risk of subjects with and without MS with the simplified 10-year Framingham General Cardiovascular Disease Risk Score (FR) and to evaluate its importance on MS-related outcomes.
Age, gender, smoking status, body mass index, systolic blood pressure, type II diabetes and use of antihypertensive medications were recorded in subjects with and without MS to estimate the FR, an individualized percentage risk score estimating the 10-year likelihood of cardiovascular events.
In total, 265 MS subjects were identified with 530 matched controls. A t test showed similar FR in cases and controls (P = 0.212). Secondary progressive MS presented significantly higher FR compared to relapsing-remitting MS (P < 0.001). Linear regression analysis showed a direct relationship between FR and Expanded Disability Status Scale (P < 0.001) and MS Severity Scale (P < 0.001).
The FR, evaluating the global cardiovascular health by the interaction amongst different risk factors, relates to MS disability, severity and course.
心血管危险因素会增加多发性硬化症（MS）的风险，并改变其病程。然而，这些因素可能相互作用，从而确定整体心血管风险。我们的目的是比较有和无 MS 的患者的整体心血管风险与简化的 10 年 Framingham 一般心血管疾病风险评分（FR），并评估其对 MS 相关结局的重要性。
记录有和无 MS 的患者的年龄、性别、吸烟状况、体重指数、收缩压、2 型糖尿病和使用降压药物的情况，以估计 FR，这是一种个体化的百分比风险评分，用于估计 10 年内发生心血管事件的可能性。
共确定了 265 例 MS 患者，有 530 例匹配对照。t 检验显示病例和对照组的 FR 相似（P=0.212）。继发进展型 MS 的 FR 明显高于复发缓解型 MS（P<0.001）。线性回归分析显示 FR 与扩展残疾状况量表（EDSS）（P<0.001）和 MS 严重程度量表（MSSS）（P<0.001）呈直接关系。
FR 通过不同危险因素的相互作用评估整体心血管健康，与 MS 的残疾、严重程度和病程相关。
