Translational Cardiomyology Lab, Embryo and Stem Cell Biology Unit, Dept of Development and Regeneration, KU Leuven, Belgium; Interuniversity Institute of Myology (IIM), Italy.
Translational Cardiomyology Lab, Embryo and Stem Cell Biology Unit, Dept of Development and Regeneration, KU Leuven, Belgium; Division of Human Anatomy, Dept of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy; Interuniversity Institute of Myology (IIM), Italy.
Adv Drug Deliv Rev. 2015 Jul 1;88:37-52. doi: 10.1016/j.addr.2015.04.011. Epub 2015 Apr 22.
microRNAs (miRs) are small non-protein-coding RNAs, able to post-transcriptionally regulate many genes and exert pleiotropic effects. Alteration of miR levels in tissues and in the circulation has been associated with various pathological and regenerative conditions. In this regard, tissue engineering of cardiac and skeletal muscles is a fascinating context for harnessing the complexity of miR-based circuitries and signals. In this review, we will focus on miR-driven regulation of cardiac and skeletal myogenic routes in homeostatic and challenging states. Furthermore, we will survey the intriguing perspective of exosomal and circulating miRs as novel paracrine players, potentially useful for current and future approaches of regenerative medicine for the striated muscles.
微小 RNA（miRs）是小型非蛋白编码 RNA，能够在后转录水平上调节许多基因并发挥多效性作用。组织和循环中 miR 水平的改变与各种病理和再生情况有关。在这方面，心脏和骨骼肌的组织工程是利用基于 miR 的电路和信号复杂性的迷人背景。在这篇综述中，我们将重点关注 miR 驱动的心脏和骨骼肌成肌途径在稳态和挑战性状态下的调节。此外，我们还将调查外泌体和循环 miR 作为新型旁分泌因子的有趣观点，它们可能对当前和未来的横纹肌再生医学方法有用。
