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告知还是不告知:南非一项三期杀微生物剂疗效试验中的男性伴侣参与情况。

To tell or not to tell: male partner engagement in a Phase 3 microbicide efficacy trial in South Africa.

作者信息

Kelly Christine A, Friedland Barbara A, Morar Neetha S, Katzen Lauren L, Ramjee Gita, Mokgatle Mathildah M, Ahmed Khatija

机构信息

a Population Council , New York , USA.

出版信息

Cult Health Sex. 2015;17(8):1004-20. doi: 10.1080/13691058.2015.1030451. Epub 2015 Apr 27.

DOI:10.1080/13691058.2015.1030451
PMID:25913101
Abstract

Gender norms that privilege men's sexual power and pleasure, and distrust of condom use in intimate relationships, leave women vulnerable to HIV and other sexually transmitted infections. Vaginal microbicides allow women to exert a degree of control over their sexual health, through responsibility for product insertion as well as the possibility of covert use. In practice, however, the uptake of new HIV-prevention products is heavily influenced by partnership dynamics. This paper presents a secondary analysis of data from two qualitative sub-studies conducted during a Phase 3 microbicide efficacy trial in South Africa. Using transcripts from in-depth interviews and focus group discussions with 278 female trial participants and 27 male partners, we investigated the extent to which women disclosed microbicide use to their partners, and the level and types of male engagement with microbicide use. Most women chose to communicate with their partners about the trial, but the timing and content of associated discussions differed according to their motivation for disclosure. Men provided their partners with both moral and practical support, but reported a desire for greater involvement in decision-making surrounding microbicide uptake and use. The findings inform recommendations for constructive male participation in future trials and, ultimately, introduction of a marketed product.

摘要

那些赋予男性性权力和性快感特权的性别规范,以及在亲密关系中对使用避孕套的不信任,使女性容易感染艾滋病毒和其他性传播感染。阴道杀微生物剂使女性能够通过负责产品插入以及秘密使用的可能性,对自身性健康施加一定程度的控制。然而,在实际中,新型艾滋病毒预防产品的采用受到伴侣关系动态的严重影响。本文对在南非进行的一项3期杀微生物剂疗效试验期间开展的两项定性子研究的数据进行了二次分析。利用对278名女性试验参与者和27名男性伴侣进行的深入访谈及焦点小组讨论的文字记录,我们调查了女性向伴侣透露使用杀微生物剂情况的程度,以及男性参与杀微生物剂使用的程度和类型。大多数女性选择与伴侣交流试验情况,但相关讨论的时机和内容因她们透露的动机而异。男性为伴侣提供了道德和实际支持,但表示希望更多地参与围绕杀微生物剂采用和使用的决策。这些研究结果为男性建设性地参与未来试验以及最终引入上市产品的建议提供了依据。

相似文献

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To tell or not to tell: male partner engagement in a Phase 3 microbicide efficacy trial in South Africa.告知还是不告知:南非一项三期杀微生物剂疗效试验中的男性伴侣参与情况。
Cult Health Sex. 2015;17(8):1004-20. doi: 10.1080/13691058.2015.1030451. Epub 2015 Apr 27.
2
Male Partner Influence on Women's HIV Prevention Trial Participation and Use of Pre-exposure Prophylaxis: the Importance of "Understanding".男性伴侣对女性参与艾滋病病毒预防试验及使用暴露前预防药物的影响:“理解”的重要性
AIDS Behav. 2015 May;19(5):784-93. doi: 10.1007/s10461-014-0950-5.
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Optimizing HIV prevention for women: a review of evidence from microbicide studies and considerations for gender-sensitive microbicide introduction.优化针对女性的艾滋病预防措施:杀微生物剂研究证据综述及引入对性别敏感的杀微生物剂的考量
J Int AIDS Soc. 2015 Dec 21;18(1):20536. doi: 10.7448/IAS.18.1.20536. eCollection 2015.
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Engaging male partners in women's microbicide use: evidence from clinical trials and implications for future research and microbicide introduction.让男性伴侣参与女性使用杀微生物剂:临床试验证据及其对未来研究和杀微生物剂推广的意义。
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The role of partnership dynamics in determining the acceptability of condoms and microbicides.伙伴关系动态在决定避孕套和杀微生物剂可接受性方面的作用。
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Prevention, Partners, and Power Imbalances: Women's Views on How Male Partners Affected Their Adherence to Vaginal Microbicide Gels During HIV Prevention Trials in Africa.预防、伴侣和权力失衡:女性对男性伴侣如何影响其在非洲艾滋病毒预防试验中坚持使用阴道杀微生物凝胶的看法。
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'The study has taught me to be supportive of her': empowering women and involving men in microbicide research.“这项研究教会了我支持她”:赋予女性权力并让男性参与杀微生物剂研究。
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Relationship Type and Use of the Vaginal Ring for HIV-1 Prevention in the MTN 020/ASPIRE Trial.关系类型和阴道环在 MTN 020/ASPIRE 试验中预防 HIV-1 的使用。
AIDS Behav. 2020 Mar;24(3):866-880. doi: 10.1007/s10461-019-02521-9.