Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain.
CIBER Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.
Int J Mol Sci. 2023 Apr 15;24(8):7325. doi: 10.3390/ijms24087325.
Bisphenols, parabens (PBs), and benzophenones (BPs) are widely used environmental chemicals that have been linked to several adverse health effects due to their endocrine disrupting properties. However, the cellular pathways through which these chemicals lead to adverse outcomes in humans are still unclear, suggesting some evidence that inflammation might play a key role. Thus, the aim of this study was to summarize the current evidence on the relationship between human exposure to these chemicals and levels of inflammatory biomarkers. A systematic review of peer-reviewed original research studies published up to February 2023 was conducted using the MEDLINE, Web of Science, and Scopus databases. A total of 20 articles met the inclusion/exclusion criteria. Most of the reviewed studies reported significant associations between any of the selected chemicals (mainly bisphenol A) and some pro-inflammatory biomarkers (including C-reactive protein and interleukin 6, among others). Taken together, this systematic review has identified consistent positive associations between human exposure to some chemicals and levels of pro-inflammatory biomarkers, with very few studies exploring the associations between PBs and/or BPs and inflammation. Therefore, a larger number of studies are required to get a better understanding on the mechanisms of action underlying bisphenols, PBs, and BPs and the critical role that inflammation could play.
双酚类、对羟基苯甲酸酯 (PBs) 和二苯甲酮 (BPs) 是广泛使用的环境化学物质，由于其内分泌干扰特性，与多种不良健康影响有关。然而，这些化学物质导致人类不良后果的细胞途径仍不清楚，这表明一些证据表明炎症可能发挥关键作用。因此，本研究旨在总结目前关于人类暴露于这些化学物质与炎症生物标志物水平之间关系的证据。使用 MEDLINE、Web of Science 和 Scopus 数据库对截至 2023 年 2 月发表的同行评审原始研究进行了系统回顾。共有 20 篇文章符合纳入/排除标准。大多数综述研究报告了所选化学物质（主要是双酚 A）与某些促炎生物标志物（包括 C 反应蛋白和白细胞介素 6 等）之间存在显著关联。综上所述，这项系统综述确定了人类暴露于某些化学物质与促炎生物标志物水平之间存在一致的正相关关系，只有极少数研究探索了 PBs 和/或 BPs 与炎症之间的关联。因此，需要更多的研究来更好地了解双酚类、PBs 和 BPs 的作用机制以及炎症可能发挥的关键作用。
