Wu Ai-Min, Shao Zhen-Xuan, Wang Jian-Shun, Yang Xin-Dong, Weng Wan-Qing, Wang Xiang-Yang, Xu Hua-Zi, Chi Yong-Long, Lin Zhong-Ke
Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Spinal Research Center, 109# Xue Yuan Western Road, Wenzhou, Zhejiang, People's Republic of China.
Department of Anatomy, Wenzhou Medical University, Higher Education Zone, Wenzhou, Zhejiang, People's Republic of China.
PLoS One. 2015 Apr 27;10(4):e0124291. doi: 10.1371/journal.pone.0124291. eCollection 2015.
To study the morphology of the human spine and new spinal fixation methods, scientists require cadaveric specimens, which are dependent on donation. However, in most countries, the number of people willing to donate their body is low. A 3D printed model could be an alternative method for morphology research, but the accuracy of the morphology of a 3D printed model has not been determined.
Forty-five computed tomography (CT) scans of cervical, thoracic and lumbar spines were obtained, and 44 parameters of the cervical spine, 120 parameters of the thoracic spine, and 50 parameters of the lumbar spine were measured. The CT scan data in DICOM format were imported into Mimics software v10.01 for 3D reconstruction, and the data were saved in .STL format and imported to Cura software. After a 3D digital model was formed, it was saved in Gcode format and exported to a 3D printer for printing. After the 3D printed models were obtained, the above-referenced parameters were measured again.
Paired t-tests were used to determine the significance, set to P<0.05, of all parameter data from the radiographic images and 3D printed models. Furthermore, 88.6% of all parameters of the cervical spine, 90% of all parameters of the thoracic spine, and 94% of all parameters of the lumbar spine had Intraclass Correlation Coefficient (ICC) values >0.800. The other ICC values were <0.800 and >0.600; none were <0.600.
In this study, we provide a protocol for printing accurate 3D spinal models for surgeons and researchers. The resulting 3D printed model is inexpensive and easily obtained for spinal fixation research.
为了研究人体脊柱的形态和新型脊柱固定方法,科学家需要尸体标本,而尸体标本依赖捐赠。然而,在大多数国家,愿意捐赠遗体的人数较少。3D打印模型可能是形态学研究的替代方法,但3D打印模型的形态准确性尚未确定。
获取了45例颈椎、胸椎和腰椎的计算机断层扫描(CT)图像,测量了颈椎的44个参数、胸椎的120个参数和腰椎的50个参数。将DICOM格式的CT扫描数据导入Mimics软件v10.01进行三维重建,数据保存为.STL格式并导入Cura软件。形成三维数字模型后,将其保存为Gcode格式并导出到3D打印机进行打印。获得3D打印模型后,再次测量上述参数。
采用配对t检验确定影像学图像和3D打印模型所有参数数据的显著性,设定P<0.05。此外,颈椎所有参数的88.6%、胸椎所有参数的90%和腰椎所有参数的94%的组内相关系数(ICC)值>0.800。其他ICC值<0.800且>0.600;无一<0.600。
在本研究中,我们为外科医生和研究人员提供了一种打印精确3D脊柱模型的方案。所得的3D打印模型价格低廉,易于获取,可用于脊柱固定研究。