用于测定工作场所空气中双硫仑的液相色谱法
[Liquid chromatography for determination of disulfiramin workplace atmosphere].
作者信息
Fu Sheng, Han Zhihui, Yu Keping, Gao Shouquan
机构信息
Hunan Prevention And Treatment Institute For Occupational Disease, Changsha 410007, China.
出版信息
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Feb;33(2):133-4.
OBJECTIVE
To establish a method for determination of disulfiram in the workplace atmosphere by liquid chromatography.
METHODS
Sampling with glass fiber filter, eluting with methanol, separating with C18 column, and determination with liquid chromatography.
RESULTS
The bearing capacity of glass fiber filter exceeded 3.45 mg per piece. The elution efficiency was 97.8%∼101.0% The relative standard deviation varied from 1.09% to 1.44%. The limit of detection was 0.1 µg/ml. The minimum detectable concentration was 0.011 mg/m³ (with sampled air volume of 45 L).
CONCLUSION
The method has high selectivity, accuracy, and precision and strong applicability.
目的
建立工作场所空气中双硫仑的液相色谱测定方法。
方法
用玻璃纤维滤纸采样，甲醇洗脱，C18柱分离，液相色谱测定。
结果
玻璃纤维滤纸承载量每片超过3.45mg，洗脱效率为97.8%～101.0%，相对标准偏差为1.09%～1.44%，检出限为0.1μg/ml，最低检出浓度为0.011mg/m³（采气45L）。
结论
该方法选择性高、准确、精密，适用性强。
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