Lee Sunhee, Jang Guehwan, Lee Changhee
Animal Virology Laboratory, School of Life Sciences, College of Natural Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 702-701, Republic of Korea.
Arch Virol. 2015 Jul;160(7):1819-21. doi: 10.1007/s00705-015-2436-9. Epub 2015 Apr 29.
Porcine astrovirus (PAstV) is broadly distributed in pigs in several countries worldwide. PAstVs belong to the genus Mamastrovirus and are divided into five genetically divergent types. This study presents a molecular characterization of PAstV identified in diarrheic piglets in South Korea. The complete genome of the Korean PAstV strain KOR/KNU14-07/2014 was sequenced and analyzed to characterize PAstV circulating in South Korea. The full-length genomic sequence of KNU14-07 was determined to be 6,337 nucleotides in length and consisted of three major open reading frames (5'-ORF1a-ORF1b-ORF2-3'). The overall degree of nucleotide sequence identity was 40.8 to 72.5% between KUN14-07 and other reported PAstVs, indicating high heterogeneity among PAstVs. Genetic and phylogenetic analyses showed that the KNU14-07 strain was most closely related to the PAstV2 lineage, which is the second most common type in South Korea.
猪星状病毒（PAstV）在全球多个国家的猪群中广泛分布。PAstV属于哺乳动物星状病毒属，分为五个基因不同的类型。本研究对在韩国腹泻仔猪中鉴定出的PAstV进行了分子特征分析。对韩国PAstV毒株KOR/KNU14 - 07/2014的全基因组进行了测序和分析，以表征在韩国流行的PAstV。KNU14 - 07的全长基因组序列被确定为6337个核苷酸，由三个主要开放阅读框组成（5'-ORF1a-ORF1b-ORF2-3'）。KUN14 - 07与其他已报道的PAstV之间的核苷酸序列总体同一性为40.8%至72.5%，表明PAstV之间存在高度异质性。遗传和系统发育分析表明，KNU14 - 07毒株与PAstV2谱系关系最为密切，PAstV2谱系是韩国第二常见的类型。
