Laboratory of Veterinary Infectious Disease, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of Korea.
Department of Companion and Laboratory Animal Science, Kongju National University, Yesan-eup, Yesan 32439, Republic of Korea.
Viruses. 2024 Aug 28;16(9):1372. doi: 10.3390/v16091372.
Recently, neurological diseases associated with astroviruses (AstVs) have been reported in pigs, ruminants, minks, and humans. In 2017, neuro-invasive porcine astrovirus (Ni-PAstV) 3 was detected in the central nervous system (CNS) of pigs with encephalomyelitis in Hungary and the USA. In the process of diagnosing domestic pigs exhibiting neurological signs, histopathologic lesions of non-suppurative encephalomyelitis with meningitis, neuronal vacuolation, and gliosis were detected, and PAstV was identified using reverse transcriptase PCR in CNS samples of four pigs in three farms from August to September in 2020, South Korea. Subsequently, the ORF2 region was successfully acquired from three brain samples, facilitating subsequent analysis. Four genotypes of PAstV (PAstV1, 3, 4, and 5) were detected, and coinfection of PAstV with multiple genotypes was observed in brain samples. This is the first study to report Ni-PAstV infection in pigs in South Korea.
最近，与星状病毒（AstVs）相关的神经疾病已在猪、反刍动物、水貂和人类中报告。2017 年，在匈牙利和美国出现脑炎的猪的中枢神经系统（CNS）中检测到神经侵袭性猪星状病毒（Ni-PAstV）3。在诊断出现神经症状的家猪的过程中，检测到非化脓性脑脊髓炎伴有脑膜脑炎、神经元空泡化和神经胶质增生的组织病理学病变，并在 2020 年 8 月至 9 月韩国三个农场的四头猪的 CNS 样本中使用逆转录酶 PCR 鉴定出 PAstV。随后，成功从三个脑组织样本中获得 ORF2 区，便于后续分析。检测到四种 PAstV 基因型（PAstV1、3、4 和 5），并在脑组织样本中观察到 PAstV 与多种基因型的混合感染。这是首次在韩国报道猪 Ni-PAstV 感染。
