Celli Jean
Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Cell Microbiol. 2015 Jul;17(7):951-8. doi: 10.1111/cmi.12452. Epub 2015 May 15.
Bacteria of the genus Brucella are intracellular vacuolar pathogens of mammals that cause the worldwide zoonosis brucellosis, and reside within phagocytes of infected hosts to promote their survival, persistence and proliferation. These traits are essential to the bacterium's ability to cause disease and have been the subject of much investigation to gain an understanding of Brucella pathogenic mechanisms. Although the endoplasmic reticulum-derived nature of the Brucella replicative niche has been long known, major strides have recently been made in deciphering the molecular mechanisms of its biogenesis, including the identification of bacterial determinants and host cellular pathways involved in this process. Here I will review and discuss the most recent advances in our knowledge of Brucella intracellular pathogenesis, with an emphasis on bacterial exploitation of the host endoplasmic reticulum-associated functions, and how autophagy-related processes contribute to the bacterium's intracellular cycle.
布鲁氏菌属细菌是哺乳动物细胞内的液泡病原体，可引发全球范围的人畜共患病布鲁氏菌病，它们寄生于受感染宿主的吞噬细胞内，以促进自身的存活、持续存在和增殖。这些特性对于该细菌致病能力至关重要，并且一直是诸多研究的主题，目的是了解布鲁氏菌的致病机制。尽管布鲁氏菌复制微环境源自内质网这一特性早已为人所知，但最近在破解其生物发生的分子机制方面取得了重大进展，包括确定参与这一过程的细菌决定因素和宿主细胞途径。在此，我将回顾并讨论我们对布鲁氏菌细胞内致病机制认识的最新进展，重点是细菌对宿主内质网相关功能的利用，以及自噬相关过程如何促进细菌的细胞内循环。
