Mortz Charlotte G, Andersen Klaus E, Bindslev-Jensen Carsten
Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.
Acta Derm Venereol. 2015 Nov;95(8):968-72. doi: 10.2340/00015555-2128.
Atopic dermatitis (AD) is a common disease in childhood and an important risk factor for the later development of other atopic diseases. Many publications on childhood AD use questionnaires based on information obtained in adulthood, which introduce the possibility of recall bias. In a prospective cohort study, recall bias was evaluated in 1,501 unselected schoolchildren (mean age 14 years) evaluated for the first time in 1995 with a standardized questionnaire combined with a clinical examination and repeated in 2010. The lifetime prevalence of AD was 34.1% including data obtained both during school age and 15 years later, compared with 23.6% including data only from adulthood. The most important factors for remembering having had AD in childhood were: (i) long duration of dermatitis in childhood; (ii) adult hand eczema; and (iii) concomitant atopic disease. Recall bias for childhood AD affected the results of logistic regression on adult hand eczema and is a significant problem in retrospective epidemiological questionnaire studies evaluating previous AD as a risk factor for development of other diseases.
特应性皮炎（AD）是一种常见的儿童疾病，也是日后发生其他特应性疾病的重要危险因素。许多关于儿童AD的出版物使用的问卷是基于成年后获得的信息，这就引入了回忆偏倚的可能性。在一项前瞻性队列研究中，对1995年首次使用标准化问卷结合临床检查进行评估的1501名未经筛选的学童（平均年龄14岁）进行了回忆偏倚评估，并于2010年进行了重复评估。AD的终生患病率为34.1%，包括学龄期和15年后获得的数据，而仅包括成年期数据的患病率为23.6%。回忆起儿童期患过AD的最重要因素是：（i）儿童期皮炎病程长；（ii）成人手部湿疹；（iii）伴有其他特应性疾病。儿童AD的回忆偏倚影响了关于成人手部湿疹的逻辑回归结果，并且在将既往AD作为其他疾病发生风险因素的回顾性流行病学问卷研究中是一个重大问题。
