Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Acta Derm Venereol. 2022 Jun 15;102:adv00737. doi: 10.2340/actadv.v102.575.
This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic dermatitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Eczema Area Severity Index (EASI). DNA was analysed for filaggrin gene mutations. Parents were asked about environmental exposures and emollient use. Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, p < 0.001), with lower age of onset (4 vs 6 months, p < 0.05) and more severe disease at onset (EASI: 4.8 vs 0.4, p < 0.0005). Environmental risk factors for atopic dermatitis were essentially similar for preterm and term born children, apart from winter and autumn births. Filaggrin gene mutations were less common in preterm than term children (4.1% vs 9.2%, p = 0.06).
本前瞻性出生队列研究在生命的第一年中跟踪了 150 名早产儿和 300 名足月新生儿，以评估特应性皮炎的危险因素、发病年龄、解剖部位和严重程度方面的可能差异。特应性皮炎通过临床诊断，使用湿疹面积严重指数（EASI）评估严重程度。分析了丝聚蛋白基因突变的 DNA。询问了父母有关环境暴露和保湿剂使用的情况。在生命的第一年观察到 21.2%的儿童患有特应性皮炎，与早产儿相比，足月儿中更常见（26.7%比 11.7%，p<0.001），发病年龄更早（4 个月比 6 个月，p<0.05），发病时疾病更严重（EASI：4.8 比 0.4，p<0.0005）。除了冬季和秋季出生外，特应性皮炎的环境危险因素对于早产儿和足月儿的基本相似。丝聚蛋白基因突变在早产儿中比足月儿中更少见（4.1%比 9.2%，p=0.06）。
