Shuai Cijun, Han Zikai, Feng Pei, Gao Chengde, Xiao Tao, Peng Shuping
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, 410083, China.
J Mater Sci Mater Med. 2015 May;26(5):188. doi: 10.1007/s10856-015-5513-4. Epub 2015 Apr 28.
Akermanite (AKM) is considered to be a promising bioactive material for bone tissue engineering due to the moderate biodegradability and excellent biocompatibility. However, the major disadvantage of AKM is the relatively inadequate fracture toughness, which hinders the further applications. In the study, boron nitride nanosheets (BNNSs) reinforced AKM scaffolds are fabricated by selective laser sintering. The effects of BNNSs on the mechanical properties and microstructure are investigated. The results show that the compressive strength and fracture toughness increase significantly with BNNSs increasing from 0.5 to 1.0 wt%. The remarkable improvement is ascribed to pull out and grain wrapping of BNNSs with AKM matrix. While, overlapping sheets is observed when more BNNSs are added, which results in the decline of mechanical properties. In addition, it is found that the composite scaffolds possess good apatite-formation ability when soaking in simulated body fluids, which have been confirmed by energy dispersed spectroscopy and flourier transform infrared spectroscopy. Moreover, MG63 osteoblast-like cells and human bone marrow stromal cells are seeded on the scaffolds. Scanning electron microscopy analysis confirms that both cells adhere and proliferate well, indicating favorable cytocompatibility. All the facts demonstrate the AKM scaffolds reinforced by BNNSs have potential applications for tissue engineering.
钙黄长石（AKM）由于具有适度的生物降解性和优异的生物相容性，被认为是骨组织工程中有前景的生物活性材料。然而，AKM的主要缺点是断裂韧性相对不足，这阻碍了其进一步应用。在该研究中，通过选择性激光烧结制备了氮化硼纳米片（BNNSs）增强的AKM支架。研究了BNNSs对力学性能和微观结构的影响。结果表明，随着BNNSs含量从0.5 wt%增加到1.0 wt%，抗压强度和断裂韧性显著提高。这种显著的改善归因于BNNSs与AKM基体之间的拔出和晶粒包裹。然而，当添加更多BNNSs时，观察到片层重叠，这导致力学性能下降。此外，发现复合支架浸泡在模拟体液中时具有良好的磷灰石形成能力，这已通过能谱和傅里叶变换红外光谱得到证实。此外，将MG63成骨样细胞和人骨髓基质细胞接种在支架上。扫描电子显微镜分析证实两种细胞均能良好地黏附并增殖，表明具有良好的细胞相容性。所有这些事实表明，BNNSs增强的AKM支架在组织工程中具有潜在应用。
