Emanet Melis, Sen Özlem, Taşkin Irem Çulha, Çulha Mustafa
Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Front Bioeng Biotechnol. 2019 Dec 10;7:363. doi: 10.3389/fbioe.2019.00363. eCollection 2019.
Two-dimensional boron nitride nanostructures (2D-BNNs) have been increasingly investigated for their applications in several scientific and technological areas. This considerable interest is due to their unique physicochemical properties, which include high hydrophobicity, heat and electrical insulation, resistance to oxidation, antioxidation capacity, thermal conductivity, high chemical stability, mechanical strength, and hydrogen storage capacity. They are also used as fillers, antibacterial agents, protective coating agents, lubricants, boron neutron capture therapy agents, nanocarriers for drug delivery, and for the receptor phase in chemosensors. The investigations for their use in medicine and biomedicine are very promising, including cancer therapy and wound healing. In this review, 2D-BNNs synthesis and their surface modification strategies, biocompatibility, and bioapplication studies are discussed. Finally, a perspective for the future use of these novel nanomaterials in the biomedical field is provided.
二维氮化硼纳米结构（2D-BNNs）因其在多个科技领域的应用而受到越来越多的研究。这种浓厚的兴趣源于其独特的物理化学性质，包括高疏水性、热绝缘和电绝缘性、抗氧化性、抗氧化能力、热导率、高化学稳定性、机械强度以及储氢能力。它们还用作填料、抗菌剂、防护涂层剂、润滑剂、硼中子俘获治疗剂、药物递送的纳米载体以及化学传感器中的受体相。对其在医学和生物医学中的应用研究非常有前景，包括癌症治疗和伤口愈合。在本综述中，讨论了二维氮化硼纳米结构的合成及其表面改性策略、生物相容性和生物应用研究。最后，对这些新型纳米材料在生物医学领域的未来应用前景进行了展望。
