Lemire Joe A, Kalan Lindsay, Bradu Alexandru, Turner Raymond J
The Biofilm Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Exciton Technologies Inc., Edmonton, AB, Canada.
Antimicrob Agents Chemother. 2015 Jul;59(7):4031-9. doi: 10.1128/AAC.05177-14. Epub 2015 Apr 27.
Historically it has been accepted, and recent research has established, that silver (Ag) is an efficacious antimicrobial agent. A dwindling pipeline of new antibiotics, combined with an increase in the number of antibiotic-resistant infections, is bringing Ag to the fore as a therapeutic compound to treat infectious diseases. Currently, many formulations of Ag are being deployed for commercial and medical purposes, with various degrees of effectiveness at killing microbial cells. Here, we evaluated the antimicrobial and antibiofilm capacity of our lead compound, silver oxynitrate [Ag(Ag3O4)2NO3 or Ag7NO11], against other metal compounds with documented antimicrobial activity, including Ag2SO4, AgNO3, silver sulfadiazine (AgSD), AgO, Ag2O, and CuSO4. Our findings reveal that Ag7NO11 eradicates biofilm and planktonic populations of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, uropathogenic Escherichia coli (UPEC), fluoroquinolone-resistant Pseudomonas aeruginosa (FQRP), and methicillin-resistant Staphylococcus aureus (MRSA) at lower concentrations than those of the other tested metal salts. Altogether, our results demonstrate that Ag7NO11 has an enhanced efficacy for the treatment of biofilm-forming pathogens.
从历史上看，银（Ag）是一种有效的抗菌剂这一观点已被接受，并且最近的研究也证实了这一点。新抗生素研发渠道的日益缩减，再加上抗生素耐药性感染数量的增加，使得银作为一种治疗传染病的治疗性化合物而备受关注。目前，许多银制剂正被用于商业和医疗目的，在杀死微生物细胞方面具有不同程度的效果。在此，我们评估了我们的先导化合物硝酸氧银[Ag(Ag3O4)2NO3或Ag7NO11]与其他已记录有抗菌活性的金属化合物（包括Ag2SO4、AgNO3、磺胺嘧啶银（AgSD）、AgO、Ag2O和CuSO4）相比的抗菌和抗生物膜能力。我们的研究结果表明，与其他测试的金属盐相比，Ag7NO11能在更低浓度下根除铜绿假单胞菌、大肠杆菌、金黄色葡萄球菌、尿路致病性大肠杆菌（UPEC）、耐氟喹诺酮铜绿假单胞菌（FQRP）和耐甲氧西林金黄色葡萄球菌（MRSA）的生物膜和浮游菌群体。总之，我们的结果表明Ag7NO11在治疗形成生物膜的病原体方面具有增强的疗效。
