Valente Pedro Miguel Ds, Deva Anand, Ngo Quan, Vickery Karen
Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
Department of Plastic and Reconstructive Surgery, Liverpool Hospital, Sydney, NSW, Australia.
Int Wound J. 2016 Feb;13(1):130-6. doi: 10.1111/iwj.12248. Epub 2014 Apr 8.
Chronic wounds remain a significant medical and financial burden in hospitals of today. A major factor in the transition from an acute to a chronic wound is its bacterial bioburden. Developments in molecular techniques have shown that chronic wounds remain colonised by many species of bacteria and that the bacteria within these chronic wounds exist in two forms. Treatments of chronic wounds have maintained a challenging field and significant ongoing research is being conducted. With the development of an in vitro wound model, we applied topical negative pressure (TNP) dressings to a spectrum of common bacterial biofilms found in chronic wounds and studied the synergistic efficacy between the application of TNP and silver-impregnated foam against these biofilms. This synergistic response was seen within the laboratory strains of staphylococcal biofilms over a 3-day treatment period but lost following the 5 days of treatment. However, combining topical pressure dressings and silver foam lead to a synergistic inactivation in Pseudomonas species over both 3-day and 5-day treatments.
在当今医院中，慢性伤口仍然是一个重大的医学和经济负担。从急性伤口转变为慢性伤口的一个主要因素是其细菌生物负荷。分子技术的发展表明，慢性伤口仍然被多种细菌定植，并且这些慢性伤口内的细菌以两种形式存在。慢性伤口的治疗一直是一个具有挑战性的领域，目前正在进行大量的研究。随着体外伤口模型的发展，我们将局部负压（TNP）敷料应用于慢性伤口中发现的一系列常见细菌生物膜，并研究了TNP与含银泡沫对这些生物膜的协同疗效。在3天的治疗期内，在葡萄球菌生物膜的实验室菌株中观察到这种协同反应，但在治疗5天后消失。然而，在3天和5天的治疗中，联合使用局部压力敷料和银泡沫导致假单胞菌属的协同失活。
