Iaconis Antonella, De Plano Laura Maria, Caccamo Antonella, Franco Domenico, Conoci Sabrina
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
Microorganisms. 2024 Mar 22;12(4):639. doi: 10.3390/microorganisms12040639.
Biofilm (BF) can give rise to systemic infections, prolonged hospitalization times, and, in the worst case, death. This review aims to provide an overview of recent strategies for the prevention and destruction of pathogenic BFs. First, the main phases of the life cycle of BF and maturation will be described to identify potential targets for anti-BF approaches. Then, an approach acting on bacterial adhesion, quorum sensing (QS), and the extracellular polymeric substance (EPS) matrix will be introduced and discussed. Finally, bacteriophage-mediated strategies will be presented as innovative approaches against BF inhibition/destruction.
生物膜（BF）可引发全身感染、延长住院时间，最严重时可导致死亡。本综述旨在概述近期预防和破坏致病性生物膜的策略。首先，将描述生物膜生命周期和成熟的主要阶段，以确定抗生物膜方法的潜在靶点。然后，将介绍并讨论一种作用于细菌黏附、群体感应（QS）和细胞外聚合物（EPS）基质的方法。最后，将介绍噬菌体介导的策略，作为抗生物膜抑制/破坏的创新方法。
