基于细胞毒性试验从链霉菌属菌株IFM11607中分离β-吲哚霉素酮及其双键构型的修正。
Isolation of β-indomycinone guided by cytotoxicity tests from Streptomyces sp. IFM11607 and revision of its double bond geometry.
作者信息
Tsukahara Kentaro, Toume Kazufumi, Ito Hanako, Ishikawa Naoki, Ishibashi Masami
出版信息
Nat Prod Commun. 2014 Sep;9(9):1327-8.
PMID:25918804
Abstract
The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its δ17,18-double bond was revised from E to Z based on the coupling constant.
摘要
抗生素β-吲哚霉素酮是通过对人胃腺癌AGS细胞进行细胞毒性导向分级分离，从链霉菌属IFM11607中分离得到的，并且根据耦合常数将其δ17,18-双键的几何构型从E型修正为Z型。
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