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Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.

作者信息

Gao Linda, van den Hurk Karin, Nsengimana Jérémie, Laye Jonathan P, van den Oord Joost J, Beck Samuel, Gruis Nelleke A, Zoutman Willem H, van Engeland Manon, Newton-Bishop Julia A, Winnepenninckx Véronique J, van Doorn Remco

机构信息

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

出版信息

J Invest Dermatol. 2015 Sep;135(9):2328-2331. doi: 10.1038/jid.2015.163. Epub 2015 Apr 28.

DOI:10.1038/jid.2015.163
PMID:25918983
Abstract
摘要

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Pigment Cell Melanoma Res. 2015 Jan;28(1):94-104. doi: 10.1111/pcmr.12315. Epub 2014 Oct 1.
2
KIT is a frequent target for epigenetic silencing in cutaneous melanoma.KIT 是皮肤黑色素瘤中表观遗传沉默的常见靶点。
J Invest Dermatol. 2015 Feb;135(2):516-524. doi: 10.1038/jid.2014.372. Epub 2014 Sep 1.
3
Prostate cancer cell migration induced by myopodin isoforms is associated with formation of morphologically and biochemically distinct actin networks.
微小RNA表达分析显示，突触足蛋白-2作为结直肠癌和宫颈癌一种新的预后及治疗生物标志物得到了关键确认。
Heliyon. 2021 Jun 19;7(6):e07347. doi: 10.1016/j.heliyon.2021.e07347. eCollection 2021 Jun.
4
Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway.突触足蛋白-2通过PI3K/Akt/mTOR信号通路在乳腺癌转移中发挥重要作用。
Cancer Manag Res. 2018 Jun 18;10:1575-1583. doi: 10.2147/CMAR.S162670. eCollection 2018.
5
DNA methylation/hydroxymethylation in melanoma.黑色素瘤中的DNA甲基化/羟甲基化
Oncotarget. 2017 May 30;8(44):78163-78173. doi: 10.18632/oncotarget.18293. eCollection 2017 Sep 29.
肌联蛋白异构体诱导的前列腺癌细胞迁移与形态和生化上不同的肌动蛋白网络的形成有关。
FASEB J. 2013 Dec;27(12):5046-58. doi: 10.1096/fj.13-231571. Epub 2013 Sep 4.
4
Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma.全基因组启动子甲基化分析鉴定出原发性皮肤黑素瘤中 MAPK13 的表观遗传沉默。
Pigment Cell Melanoma Res. 2013 Jul;26(4):542-54. doi: 10.1111/pcmr.12096. Epub 2013 Apr 17.
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Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients.全基因组甲基化谱作为 IIIC 期黑色素瘤患者生存的独立标志物。
J Transl Med. 2012 Sep 5;10:185. doi: 10.1186/1479-5876-10-185.
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Epigenetic disruption of cadherin-11 in human cancer metastasis.人类癌症转移中钙黏蛋白 11 的表观遗传失调。
J Pathol. 2012 Oct;228(2):230-40. doi: 10.1002/path.4011. Epub 2012 Jul 26.
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Myopodin methylation is associated with clinical outcome in patients with T1G3 bladder cancer.肌联蛋白甲基化与 T1G3 膀胱癌患者的临床结局相关。
J Urol. 2010 Oct;184(4):1507-13. doi: 10.1016/j.juro.2010.05.085. Epub 2010 Aug 17.
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Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival.采用 DASL 检测对石蜡包埋原发性黑素瘤进行基因表达谱分析，发现骨桥蛋白表达增加与降低无复发生存率相关。
Clin Cancer Res. 2009 Nov 15;15(22):6939-46. doi: 10.1158/1078-0432.CCR-09-1631. Epub 2009 Nov 3.