[妊娠期糖尿病患者胎盘内内脏脂肪素的表达]
[The expression of visfatin in placenta in women with gestational diabetes mellitus].
作者信息
Luo Jia-xi, Liu Xing-hui, Zhang Li, He Guo-lin
机构信息
Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar;42(2):204-7.
OBJECTIVE
To explore the relationship between the expression of visfatin in placenta and the pathological process of gestational diabetes mellitus (GDM).
METHODS
The expression of visfatin mRNA in placenta was measured by RT-PCR in 50 women with GDM (GDM group) and 50 women with normal term pregnancy (control group). The clinical indexes of the pregnant women and their children were assessed by specially trained medical staff.
RESULTS
The expression level of visfatin in placenta was as high as house-keeping gene---GAPDH; There was no significant difference in the expression of visfatin between the GDM group and the control group; The partial correlation analysis showed that the expression levels of visfatin mRNA in placenta negatively correlated to glucose screening test (GCT) blood glucose and neonatal body mass index, and positively correlated to body mass index, abdominal circumference and number of pregnancies of the pregnant women.
CONCLUSION
Visfatin may be involved in the pathogenesis of gestational diabetes mellitus.
目的
探讨胎盘内内脏脂肪素的表达与妊娠期糖尿病（GDM）病理过程之间的关系。
方法
采用逆转录-聚合酶链反应（RT-PCR）法检测50例GDM孕妇（GDM组）和50例足月正常妊娠孕妇（对照组）胎盘组织中内脏脂肪素mRNA的表达。由经过专门培训的医务人员评估孕妇及其子女的临床指标。
结果
胎盘内内脏脂肪素的表达水平与管家基因——甘油醛-3-磷酸脱氢酶（GAPDH）相当；GDM组与对照组内脏脂肪素的表达无显著差异；偏相关分析显示，胎盘组织中内脏脂肪素mRNA的表达水平与葡萄糖筛查试验（GCT）血糖及新生儿体重指数呈负相关，与孕妇体重指数、腹围及妊娠次数呈正相关。
结论
内脏脂肪素可能参与妊娠期糖尿病的发病机制。
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