Onwuneme Chike, Martin Fidelma, McCarthy Roberta, Carroll Aoife, Segurado Ricardo, Murphy John, Twomey Anne, Murphy Nuala, Kilbane Mark, McKenna Malachi, Molloy Eleanor
Department of Neonatology, National Maternity Hospital, Dublin, Ireland; Department of Endocrinology, Children's University Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
J Pediatr. 2015 May;166(5):1175-1180.e1. doi: 10.1016/j.jpeds.2015.01.055.
To assess the association between serum 25-hydroxyvitamin D (25OHD) levels and outcomes in preterm infants (<32 weeks gestation).
Serum 25OHD was measured in mothers and their infants within 24 hours of birth, before the start of enteral vitamin D supplementation, and at discharge from the neonatal intensive care unit. We evaluated the associations between vitamin D status and various early preterm outcomes.
Ninety-four preterm infants and their mothers were included; 92% of the infants had a 25OHD level≤50 nmol/L (20 ng/mL), and 64% had a 25OHD level<30 nmol/L (12 ng/mL). A low 25OHD level (<30 nmol/L) in preterm infants at birth was associated with increased oxygen requirement (P=.008), increased duration of intermittent positive-pressure ventilation during resuscitation at delivery (P=.032), and greater need for assisted ventilation (P=.013).
We observed a high prevalence of low 25OHD (<30 nmol/L), and found an association between vitamin D status and acute respiratory morbidity in preterm infants after birth.
评估血清25-羟基维生素D（25OHD）水平与孕周<32周的早产儿预后之间的关联。
在母亲及其婴儿出生后24小时内、开始肠内补充维生素D之前以及从新生儿重症监护病房出院时测量血清25OHD。我们评估了维生素D状态与各种早期早产结局之间的关联。
纳入了94名早产儿及其母亲；92%的婴儿25OHD水平≤50 nmol/L（20 ng/mL），64%的婴儿25OHD水平<30 nmol/L（12 ng/mL）。出生时早产儿低25OHD水平（<30 nmol/L）与吸氧需求增加（P = 0.008）、分娩复苏期间间歇正压通气持续时间增加（P = 0.032）以及辅助通气需求增加（P = 0.013）相关。
我们观察到低25OHD（<30 nmol/L）的高患病率，并发现维生素D状态与出生后早产儿急性呼吸疾病之间存在关联。
