Stalnaker Thomas A, Cooch Nisha K, Schoenbaum Geoffrey
National Institute on Drug Abuse Intramural Research Program, US National Institutes of Health, Baltimore, Maryland, USA.
Nat Neurosci. 2015 May;18(5):620-7. doi: 10.1038/nn.3982.
The number of papers about the orbitofrontal cortex (OFC) has grown from 1 per month in 1987 to a current rate of over 50 per month. This publication stream has implicated the OFC in nearly every function known to cognitive neuroscience and in most neuropsychiatric diseases. However, new ideas about OFC function are typically based on limited data sets and often ignore or minimize competing ideas or contradictory findings. Yet true progress in our understanding of an area's function comes as much from invalidating existing ideas as proposing new ones. Here we consider the proposed roles for OFC, critically examining the level of support for these claims and highlighting the data that call them into question.
关于眶额皮质(OFC)的论文数量已从1987年的每月1篇增长到目前的每月50多篇。这一发表趋势表明,眶额皮质几乎涉及认知神经科学已知的每一项功能以及大多数神经精神疾病。然而,关于眶额皮质功能的新观点通常基于有限的数据集,并且常常忽视或淡化相互竞争的观点或相互矛盾的研究结果。然而,我们对一个区域功能的真正理解,不仅来自于提出新观点,也同样来自于推翻现有观点。在此,我们探讨眶额皮质的假定作用,批判性地审视这些观点的支持程度,并突出那些使其受到质疑的数据。
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