枕孢菌素A、禾本科菌素C和顺式灰菌素B——来自亚利桑那柏真菌内生菌枕孢菌属11120的新型天然呋喃酮。
Pulvinulin A, graminin C, and cis-gregatin B--new natural furanones from Pulvinula sp. 11120, a fungal endophyte of Cupressus arizonica.
作者信息
Wijeratne E M Kithsiri, Xu Yaming, Arnold A Elizabeth, Gunatilaka A A Leslie
出版信息
Nat Prod Commun. 2015 Jan;10(1):107-11.
Abstract
Three new natural furanones, pulvinulin A (1), graminin C (2), and cis-gregatin B (3), together with the known fungal metabolites, graminin B (4) and 10-norparvulenone (5), were isolated from Pulvinula sp. 11120, an endophytic fungal strain occurring in healthy foliage of Cupressus arizonica (Arizona cypress). The structures of 1 and 2 were elucidated by the analysis of their spectroscopic data and chemical interconversions, and that of 3 was determined by comparison with data for synthetic cis-gregatin B. Comparison of spectroscopic data of 4 and 5 with those reported identified them as graminin B and 10-norparvulenone, respectively. Metabolites 1-4 exhibited antibacterial activity against E. coli.
摘要
从生长于亚利桑那柏（Arizona cypress）健康叶片中的内生真菌菌株Pulvinula sp. 11120中分离出三种新的天然呋喃酮，即pulvinulin A（1）、graminin C（2）和顺式gregatin B（3），以及已知的真菌代谢产物graminin B（4）和10-去甲parvulenone（5）。通过对其光谱数据和化学转化的分析阐明了1和2的结构，通过与合成顺式gregatin B的数据比较确定了3的结构。将4和5的光谱数据与报道的数据进行比较，分别鉴定它们为graminin B和10-去甲parvulenone。代谢产物1 - 4对大肠杆菌表现出抗菌活性。
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