一种从药用真菌椭圆嗜蓝孢孔菌中提取的新型抗氧化剂吡喃并[4,3-c][2]苯并吡喃-1,6-二酮衍生物。
A new antioxidant pyrano[4,3-c][2]benzopyran-1,6-dione derivative from the medicinal mushroom Fomitiporia ellipsoidea.
作者信息
Zan Li Feng, Bao Hai Ying, Bau Tolgor, Li Yu
出版信息
Nat Prod Commun. 2015 Feb;10(2):315-6.
PMID:25920271
Abstract
A new pyrano[4,3-c][2]benzopyran-1,6-dione derivative antioxidant, named phelligridin K (1), was isolated from the methanol extract of the fruiting bodies of Fomitiporia ellipsoidea, together with the known compounds, (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (2), hispidin (3), inoscavin C (4), and inonoblin B (5). Their structures were elucidated by means of extensive NMR and MS data analysis. Compounds 1, 4 and 5 exhibited significant scavenging activity against the ABTS radical cation.
摘要
从椭圆嗜蓝孢孔菌子实体的甲醇提取物中分离出一种新的吡喃并[4,3-c][2]苯并吡喃-1,6-二酮衍生物抗氧化剂，命名为桑黄亭K（1），同时还分离出了已知化合物（E）-4-（3,4-二羟基苯基）丁-3-烯-2-酮（2）、漆斑菌素（3）、香菇嘌呤C（4）和鬼笔环肽B（5）。通过广泛的核磁共振（NMR）和质谱（MS）数据分析阐明了它们的结构。化合物1、4和5对ABTS自由基阳离子表现出显著的清除活性。
相似文献
1
2
Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity.来自干腐菌的漆斑菌素衍生物及其抗氧化活性。
J Nat Prod. 2006 Feb;69(2):299-301. doi: 10.1021/np050453n.
3
Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus.来自药用真菌毛栓菌的抗氧化漆斑菌素衍生物。
Chem Pharm Bull (Tokyo). 2011;59(6):770-2. doi: 10.1248/cpb.59.770.
4
A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius.一种从真菌桑黄中分离得到的具有抗氧化和细胞毒性活性的独特的高氧化吡喃并[4,3-c][2]苯并吡喃-1,6-二酮衍生物。
Org Lett. 2005 Apr 28;7(9):1675-8. doi: 10.1021/ol0475764.
5
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.来自药用真菌桦褐孔菌的新型抗氧化多酚。
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6678-81. doi: 10.1016/j.bmcl.2007.10.072. Epub 2007 Oct 25.
6
Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus.高度氧化和不饱和的代谢产物在药用蘑菇桦褐孔菌和桑黄中提供了多种漆斑菌素类抗氧化剂。
Bioorg Med Chem. 2007 May 15;15(10):3309-14. doi: 10.1016/j.bmc.2007.03.039. Epub 2007 Mar 16.
7
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.来自蘑菇干腐菌的漆斑菌素类似物及其自由基清除活性。
Bioorg Med Chem Lett. 2006 May 1;16(9):2376-9. doi: 10.1016/j.bmcl.2006.01.121. Epub 2006 Feb 20.
8
Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis.药用真菌干腐菌中的自由基清除剂及其推测的生物合成过程。
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5621-4. doi: 10.1016/j.bmcl.2006.08.016.
9
Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau.太白菇中分离得到的五个具有抗氧化活性的疣柄牛肝菌衍生物：太白菇素 A-E。
J Nat Prod. 2013 Aug 23;76(8):1448-53. doi: 10.1021/np400234u. Epub 2013 Jul 19.
10
Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties.药食两用真菌鲍氏层孔菌中的苯并吡喃酮及其抗氧化活性
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5459-61. doi: 10.1016/j.bmcl.2010.07.093. Epub 2010 Jul 25.
引用本文的文献
1
Response surface methodology-based optimization of ' liquid fermentation medium and evaluation of its exopolysaccharide activities.基于响应面法的“液体发酵培养基优化及其胞外多糖活性评价”
Front Microbiol. 2024 Sep 4;15:1456461. doi: 10.3389/fmicb.2024.1456461. eCollection 2024.
2
Immunomodulatory, Antioxidant, and Potential Anticancer Activity of the Polysaccharides of the Fungus .真菌多糖的免疫调节、抗氧化和潜在抗癌活性。
Molecules. 2024 Jul 31;29(15):3628. doi: 10.3390/molecules29153628.
3
Screening for proteins related to the biosynthesis of hispidin and its derivatives in Phellinus igniarius using iTRAQ proteomic analysis.采用 iTRAQ 蛋白质组学分析筛选桑黄中与几丁质合成及其衍生物相关的蛋白质。
BMC Microbiol. 2021 Mar 12;21(1):81. doi: 10.1186/s12866-021-02134-0.
4
Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization.漆黄素通过抑制微管蛋白聚合使溶酶体膜通透性增加，从而诱导SGC - 7901胃癌细胞发生自噬性和坏死性死亡。
Oncotarget. 2017 Apr 18;8(16):26992-27006. doi: 10.18632/oncotarget.15935.
Zotero 插件