State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , No. 9 Beiertiao, Zhongguancun, Haidian District, Beijing 100190, People's Republic of China.
J Nat Prod. 2013 Aug 23;76(8):1448-53. doi: 10.1021/np400234u. Epub 2013 Jul 19.
Five new hispidin derivatives, phaeolschidins A-E (1-5), as well as two known natural products, pinillidine (6) and hispidin (7), were isolated from the fruiting bodies of Phaeolus schweinitzii collected in the Tibetan Plateau. The structures of the new compounds were elucidated by spectroscopic methods. Phaeolschidins A-D (1-4) are new bishispidins. Phaeolschidin E (5) is a new class of hispidin derivative in which one pyrrolidin-2-one moiety was linked to C-3 of hispidin. The antioxidant activity of 1-7 was evaluated using three methods: the DPPH scavenging assay, the total antioxidant capacity assay, and the lipid peroxidation assay. Hispidin showed the strongest antioxidant activity of all tested compounds. This is the first report of secondary metabolites from the fungus P. schweinitzii.
从采自青藏高原的灰树花中分离得到了 5 种新的棘白菌素衍生物，即 phaeolschidins A-E（1-5），以及 2 种已知天然产物，pinillidine（6）和棘白菌素（7）。通过光谱方法阐明了新化合物的结构。Phaeolschidins A-D（1-4）是新的双棘白菌素。Phaeolschidin E（5）是棘白菌素衍生物的一个新类别，其中一个吡咯烷-2-酮部分连接到棘白菌素的 C-3 上。使用三种方法评估了 1-7 的抗氧化活性：DPPH 清除试验、总抗氧化能力试验和脂质过氧化试验。棘白菌素在所有测试化合物中表现出最强的抗氧化活性。这是首次从真菌 P. schweinitzii 中分离得到的次生代谢产物。
