Raban M Shukri, Harrison Michael C
Division of Neonatal Medicine, Department of Paediatrics, University of Cape Town, 7935 Cape Town, South Africa
Division of Neonatal Medicine, Department of Paediatrics, University of Cape Town, 7935 Cape Town, South Africa.
J Trop Pediatr. 2015 Aug;61(4):266-71. doi: 10.1093/tropej/fmv027. Epub 2015 Apr 28.
Despite limited evidence, fresh frozen plasma (FFP) transfusions are a relatively common neonatal procedure.
Quantify FFP usage in our unit; determine indications for transfusions and compliance with published guidelines.
Data were retrospectively collected on infants who received FFP from January 2009 to December 2013.
Admissions totalled 10 912 infants during the study period. In total, 113 case notes were reviewed and 142 FFP transfusions were administered. Infants receiving FFP had a high mortality rate (54.87%) and an increased odds ratio for mortality 17.9 (95% confidence interval 12.0-26.6). In total, 75% FFP transfusions were compliant with guidelines. The difference between pre- and post-transfusion coagulation profile in 36.3% of infants was not statistically significant.
FFP was often used in accordance with published guidelines in our neonatal unit. However, the appropriate use and effectiveness of FFP in improving neonatal outcomes undermines the rationale for FFP usage in current guidelines.
尽管证据有限，但新鲜冰冻血浆（FFP）输血是一种相对常见的新生儿治疗手段。
量化我们科室的FFP使用情况；确定输血指征以及对已发布指南的遵循情况。
回顾性收集2009年1月至2013年12月期间接受FFP治疗的婴儿的数据。
研究期间共有10912名婴儿入院。总共审查了113份病例记录，并进行了142次FFP输血。接受FFP治疗的婴儿死亡率很高（54.87%），死亡比值比增加了17.9（95%置信区间12.0 - 26.6）。总体而言，75%的FFP输血符合指南。36.3%的婴儿输血前后凝血指标的差异无统计学意义。
在我们的新生儿科室，FFP的使用通常符合已发布的指南。然而，FFP在改善新生儿结局方面的合理使用和有效性削弱了当前指南中FFP使用的理论依据。
