Knackstedt R W, Dixon J A, O'Neill P J, Herrera F A
MUSC Division of Plastic Surgery, 96 Jonathan Lucas Street, CSB 404, MSC 613, Charleston, SC 29425, USA.
Case Rep Med. 2015;2015:642595. doi: 10.1155/2015/642595. Epub 2015 Apr 1.
Background. Bilateral reduction mammoplasty is a common plastic surgery procedure that can be complicated by unfavorable scar formation along incision sites. Surgical adhesives can be utilized as an alternative or as an adjunct to conventional suture closures to help achieve good wound tension and provide an adequate barrier with excellent cosmesis. The recently introduced DERMABOND PRINEO Skin Closure System Skin Closure System combines the skin adhesive 2-octyl cyanoacrylate with a self-adhering polyester-based mesh. Proposed benefits of wound closure with DERMABOND PRINEO Skin Closure System, used with or without sutures, include its watertight seal, easy removal, microbial barrier, even distribution of tension, and reduction in wound closure time. Although allergic reactions to 2-octyl cyanoacrylate have been reported, few allergic reactions to DERMABOND PRINEO Skin Closure System have been noted in the literature. This case series describes three patients who experienced an allergic reaction to DERMABOND PRINEO Skin Closure System after undergoing elective bilateral reduction mammoplasties at our institution to further explore this topic. Methods. Retrospective chart review of bilateral reduction mammoplasty patients who received DERMABOND PRINEO Skin Closure System dressing at our institution was performed. Results. Three patients were identified as having a rash in reaction to DERMABOND PRINEO Skin Closure System after bilateral reduction mammoplasty. All three patients required systemic steroid treatment to resolve the rash. One patient was identified as having a prior adhesive reaction. Conclusions. DERMABOND PRINEO Skin Closure System has demonstrated its efficacy in optimizing scar healing and appearance. However, as we demonstrate these three allergic reactions to DERMABOND PRINEO Skin Closure System, caution must be utilized in its usage, namely, in patients with a prior adhesive allergy and in sites where moisture or friction may be apparent.
背景。双侧乳房缩小术是一种常见的整形手术，手术切口部位可能会形成不良瘢痕，从而引发并发症。手术粘合剂可作为传统缝线缝合的替代方法或辅助手段，有助于实现良好的伤口张力，并提供具有出色美容效果的充分屏障。最近推出的DERMABOND PRINEO皮肤闭合系统将皮肤粘合剂2-辛基氰基丙烯酸酯与自粘聚酯基网布相结合。使用或不使用缝线的情况下，DERMABOND PRINEO皮肤闭合系统进行伤口闭合的潜在益处包括其防水密封、易于拆除、微生物屏障、张力均匀分布以及缩短伤口闭合时间。尽管已有对2-辛基氰基丙烯酸酯过敏反应的报道，但文献中很少提及对DERMABOND PRINEO皮肤闭合系统的过敏反应。本病例系列描述了三名患者，他们在我们机构接受择期双侧乳房缩小术后对DERMABOND PRINEO皮肤闭合系统出现过敏反应，以进一步探讨这一话题。方法。对在我们机构接受DERMABOND PRINEO皮肤闭合系统敷料的双侧乳房缩小术患者进行回顾性病历审查。结果。三名患者被确定在双侧乳房缩小术后因DERMABOND PRINEO皮肤闭合系统出现皮疹。所有三名患者均需要全身使用类固醇治疗以消退皮疹。一名患者被确定有先前的粘合剂反应。结论。DERMABOND PRINEO皮肤闭合系统已证明其在优化瘢痕愈合和外观方面的功效。然而，正如我们所展示的这三例对DERMABOND PRINEO皮肤闭合系统的过敏反应，在使用时必须谨慎，即在有先前粘合剂过敏的患者以及可能存在潮湿或摩擦的部位。
