Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland.
Department of Environmental Science, University of Eastern Finland, Kuopio, Finland.
Indoor Air. 2016 Jun;26(3):439-47. doi: 10.1111/ina.12216. Epub 2015 May 23.
This study investigated the association between confirmed moisture damage in homes and systemic subclinical inflammation in children. Home inspections were performed in homes of 291 children at the age of 6 years. Subclinical inflammation at the age of 6 years was assessed by measuring the circulating levels of C-reactive protein (CRP) and leukocytes in peripheral blood and fractional exhaled nitric oxide (FeNO). Proinflammatory cytokines interleukin (IL)-1β and IL-6 and tumor necrosis factor (TNF)-α were measured in unstimulated, and in phorbol 12-myristate 13-acetate and ionomycin (PI), lipopolysaccharide (LPS), or peptidoglycan (PPG)-stimulated whole blood. Major moisture damage in the child's main living areas (living room, kitchen, or child's bedroom) and moisture damage with mold in the bathroom were associated with increased levels of CRP and stimulated production of several proinflammatory cytokines. There were no significant associations between moisture damage/visible mold and leukocyte or FeNO values. The results suggest that moisture damage or mold in home may be associated with increased systemic subclinical inflammation and proinflammatory cytokine responsiveness.
本研究调查了家中确认的潮湿损伤与儿童系统性亚临床炎症之间的关联。在 291 名 6 岁儿童的家中进行了房屋检查。通过测量外周血中 C 反应蛋白 (CRP) 和白细胞以及呼出气一氧化氮分数 (FeNO) 的循环水平来评估 6 岁时的亚临床炎症。在未刺激、佛波醇 12-肉豆蔻酸 13-乙酸酯和离子霉素 (PI)、脂多糖 (LPS) 或肽聚糖 (PPG) 刺激的全血中测量促炎细胞因子白细胞介素 (IL)-1β 和 IL-6 和肿瘤坏死因子 (TNF)-α。儿童主要生活区域（客厅、厨房或儿童卧室）的主要潮湿损伤和浴室的潮湿损伤伴有霉菌与 CRP 水平升高和几种促炎细胞因子的刺激产生有关。潮湿损伤/可见霉菌与白细胞或 FeNO 值之间没有显著关联。结果表明，家庭中的潮湿损伤或霉菌可能与全身性亚临床炎症和促炎细胞因子反应性增加有关。
