Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Indoor Air. 2016 Jun;26(3):448-56. doi: 10.1111/ina.12213. Epub 2015 Jun 3.
We aimed to characterize the presence of microbial secondary metabolites in homes and their association with moisture damage, mold, and asthma development. Living room floor dust was analyzed by LC-MS/MS for 333 secondary metabolites from 93 homes of 1-year-old children. Moisture damage was present in 15 living rooms. At 6 years, 8 children had active and 15 lifetime doctor-diagnosed asthma. The median number of different metabolites per house was 17 (range 8-29) and median sum load 65 (4-865) ng/m(2) . Overall 42 different metabolites were detected. The number of metabolites present tended to be higher in homes with mold odor or moisture damage. The higher sum loads and number of metabolites with loads over 10 ng/m(2) were associated with lower prevalence of active asthma at 6 years (aOR 0.06 (95% CI <0.001-0.96) and 0.05 (<0.001-0.56), respectively). None of the individual metabolites, which presence tended (P < 0.2) to be increased by moisture damage or mold, were associated with increased risk of asthma. Microbial secondary metabolites are ubiquitously present in home floor dust. Moisture damage and mold tend to increase their numbers and amount. There was no evidence indicating that the secondary metabolites determined would explain the association between moisture damage, mold, and the development of asthma.
我们旨在描述家庭中微生物次生代谢物的存在情况及其与潮湿损坏、霉菌和哮喘发展的关系。通过 LC-MS/MS 对 93 户 1 岁儿童的客厅地板灰尘进行了 333 种次生代谢物分析。15 个客厅存在潮湿损坏。6 岁时，8 名儿童有活动性哮喘，15 名儿童有终身医生诊断的哮喘。每所房屋的不同代谢物中位数为 17（范围 8-29），总负荷中位数为 65（4-865）ng/m(2)。总共检测到 42 种不同的代谢物。有霉菌气味或潮湿损坏的房屋中存在的代谢物数量往往更高。负荷超过 10 ng/m(2)的代谢物的更高总负荷和数量与 6 岁时活动性哮喘的较低患病率相关（aOR 0.06（95%CI <0.001-0.96）和 0.05（<0.001-0.56））。没有一种单个代谢物（其存在倾向于（P<0.2）受潮湿损坏或霉菌的影响）与哮喘风险增加相关。微生物次生代谢物普遍存在于家庭地板灰尘中。潮湿损坏和霉菌往往会增加它们的数量和含量。没有证据表明所确定的次生代谢物可以解释潮湿损坏、霉菌与哮喘发展之间的关系。
