Institute for Health Resort Medicine and Health Promotion, State Institute of Health, Bavarian Health and Food Safety Authority, Bad Kissingen, Germany.
Institute of Social Medicine and Health Systems Research (ISMHSR), Medical faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Pediatr Allergy Immunol. 2021 Aug;32(6):1226-1237. doi: 10.1111/pai.13526. Epub 2021 May 9.
Exposure to indoor moisture damage and visible mold has been found to be associated with asthma and respiratory symptoms in several questionnaire-based studies by self-report. We aimed to define the prospective association between the early life exposure to residential moisture damage or mold and fractional exhaled nitric oxide (FeNO) and lung function parameters as objective markers for airway inflammation and asthma in 6-year-old children.
Home inspections were performed in children's homes when infants were on average 5 months old. At age 6 years, data on FeNO (n = 322) as well as lung function (n = 216) measurements were collected. Logistic regression and generalized additive models were used for statistical analyses.
Early age major moisture damage and moisture damage or mold in the child's main living areas were significantly associated with increased FeNO levels (>75th percentile) at the age of 6 years (adjusted odds ratios, 95% confidence intervals, aOR (95% CI): 3.10 (1.35-7.07) and 3.16 (1.43-6.98), respectively. Effects were more pronounced in those who did not change residential address throughout the study period. For lung function, major structural damage within the whole home was associated with reduced FEV1 and FVC, but not with FEV1/FVC. No association with lung function was observed with early moisture damage or mold in the child's main living areas.
These results underline the importance of prevention and remediation efforts of moisture and mold-damaged buildings in order to avoid harmful effects within the vulnerable phase of the infants and children's immunologic development.
几项基于问卷调查的研究发现，暴露于室内潮湿损坏和可见霉菌与哮喘和呼吸道症状有关。我们旨在确定儿童生命早期暴露于住宅潮湿损坏或霉菌与呼出气一氧化氮分数（FeNO）和肺功能参数之间的前瞻性关联，这些参数是气道炎症和哮喘的客观标志物。
当婴儿平均 5 个月大时，在儿童家中进行房屋检查。在 6 岁时，收集 FeNO（n=322）和肺功能（n=216）测量数据。使用逻辑回归和广义加性模型进行统计分析。
早期主要潮湿损坏和儿童主要生活区域的潮湿损坏或霉菌与 6 岁时 FeNO 水平升高（>第 75 百分位数）显著相关（调整后的优势比，95%置信区间，aOR（95%CI）：3.10（1.35-7.07）和 3.16（1.43-6.98））。在整个研究期间未更改居住地址的儿童中，影响更为明显。对于肺功能，整个家庭内的主要结构损坏与 FEV1 和 FVC 降低有关，但与 FEV1/FVC 无关。在儿童主要生活区域中，早期潮湿损坏或霉菌与肺功能无关。
这些结果强调了预防和修复潮湿和霉菌损坏建筑物的重要性，以避免在婴儿和儿童免疫发育的脆弱阶段产生有害影响。
