一种用于设计结核病治疗方法的多尺度方法。
A multi-scale approach to designing therapeutics for tuberculosis.
作者信息
Linderman Jennifer J, Cilfone Nicholas A, Pienaar Elsje, Gong Chang, Kirschner Denise E
机构信息
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Integr Biol (Camb). 2015 May;7(5):591-609. doi: 10.1039/c4ib00295d. Epub 2015 Apr 30.
Abstract
Approximately one third of the world's population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. We describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and
摘要
世界上约三分之一的人口感染了结核分枝杆菌。关于免疫系统如何对抗结核分枝杆菌以及什么构成对该细菌的保护的信息有限，这影响了我们开发有效结核病治疗方法的能力。我们提出了一种体内系统生物学方法，该方法将来自多个模型系统以及多个长度和时间尺度的数据整合到对结核分枝杆菌体内免疫反应的全面多尺度和多隔室视图中。我们描述了可用于研究（a）用细胞因子肿瘤坏死因子和白细胞介素10进行免疫调节，（b）口服和吸入抗生素的计算模型，以及
相似文献
1
A multi-scale approach to designing therapeutics for tuberculosis.一种用于设计结核病治疗方法的多尺度方法。
Integr Biol (Camb). 2015 May;7(5):591-609. doi: 10.1039/c4ib00295d. Epub 2015 Apr 30.
2
[Development of antituberculous drugs: current status and future prospects].[抗结核药物的研发：现状与未来前景]
Kekkaku. 2006 Dec;81(12):753-74.
3
Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.作为一种用于多尺度、多隔室计算模型的系统生物学方法的可调分辨率。
Wiley Interdiscip Rev Syst Biol Med. 2014 Jul-Aug;6(4):289-309. doi: 10.1002/wsbm.1270. Epub 2014 May 9.
4
Inhalable microparticles modify cytokine secretion by lung macrophages of infected mice.可吸入微颗粒可改变感染小鼠肺部巨噬细胞细胞因子的分泌。
Tuberculosis (Edinb). 2011 Jan;91(1):107-10. doi: 10.1016/j.tube.2010.11.003. Epub 2010 Dec 14.
5
The immunosuppressive effects of a novel recombinant LipQ (Rv2485c) protein of Mycobacterium tuberculosis on human macrophage cell lines.结核分枝杆菌新型重组LipQ（Rv2485c）蛋白对人巨噬细胞系的免疫抑制作用。
Microb Pathog. 2017 Jun;107:361-367. doi: 10.1016/j.micpath.2017.04.015. Epub 2017 Apr 12.
6
Dormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression.结核分枝杆菌休眠相关翻译抑制剂（DATIN/Rv0079）与 TLR2 相互作用，诱导促炎细胞因子表达。
Cytokine. 2013 Oct;64(1):258-64. doi: 10.1016/j.cyto.2013.06.310. Epub 2013 Jun 29.
7
Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: A Multiscale Computational Biology Approach.氧气调节肉芽肿介导的宿主对结核分枝杆菌反应的有效性：一种多尺度计算生物学方法。
Front Cell Infect Microbiol. 2016 Feb 15;6:6. doi: 10.3389/fcimb.2016.00006. eCollection 2016.
8
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.计算模型预测，在结核分枝杆菌感染期间，白细胞介素-10通过平衡早期宿主免疫介导的抗菌反应与干酪样坏死来控制病灶杀菌。
J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734. Epub 2014 Dec 15.
9
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.一种整合宿主免疫与抗生素动力学以研究结核病治疗的计算工具。
J Theor Biol. 2015 Feb 21;367:166-179. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.
10
Mathematical model for the growth of Mycobacterium tuberculosis in the granuloma.结核分枝杆菌在肉芽肿中生长的数学模型
Math Biosci Eng. 2018 Apr 1;15(2):407-428. doi: 10.3934/mbe.2018018.
引用本文的文献
1
Characterizing the immune response to : a comprehensive narrative review and implications in disease relapse.对……免疫反应的特征描述：一项全面的叙述性综述及其对疾病复发的影响
Front Immunol. 2024 Nov 22;15:1437901. doi: 10.3389/fimmu.2024.1437901. eCollection 2024.
2
In Silico Studies to Support Vaccine Development.支持疫苗研发的计算机模拟研究
Pharmaceutics. 2023 Feb 15;15(2):654. doi: 10.3390/pharmaceutics15020654.
3
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model.通过将基于空间的 agent 模型与全患者定量系统药理学模型进行耦合，模拟肿瘤生长和对免疫疗法的反应。
PLoS Comput Biol. 2022 Jul 22;18(7):e1010254. doi: 10.1371/journal.pcbi.1010254. eCollection 2022 Jul.
4
The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena.用于解释生物现象的面向机制的模型和方法的范围
Processes (Basel). 2018 May;6(5). doi: 10.3390/pr6050056. Epub 2018 May 14.
5
A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.一种计算模型可追踪全肺结核分枝杆菌感染，并预测抑制其传播的因素。
PLoS Comput Biol. 2020 May 20;16(5):e1007280. doi: 10.1371/journal.pcbi.1007280. eCollection 2020 May.
6
Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas.药代动力学变异性和肉芽肿异质性均会影响一线抗生素对结核肉芽肿进行杀菌的能力。
Front Pharmacol. 2020 Mar 24;11:333. doi: 10.3389/fphar.2020.00333. eCollection 2020.
7
In Vitro Granuloma Models of Tuberculosis: Potential and Challenges.体外结核肉芽肿模型：潜力与挑战。
J Infect Dis. 2019 May 24;219(12):1858-1866. doi: 10.1093/infdis/jiz020.
8
A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment.关于计算和数学建模对我们理解结核分枝杆菌宿主内感染及治疗所做贡献的综述。
Curr Opin Syst Biol. 2017 Jun;3:170-185. doi: 10.1016/j.coisb.2017.05.014. Epub 2017 May 22.
9
Review of the systems biology of the immune system using agent-based models.使用基于主体的模型对免疫系统的系统生物学进行综述。
IET Syst Biol. 2018 Jun;12(3):83-92. doi: 10.1049/iet-syb.2017.0073.
10
Applying optimization algorithms to tuberculosis antibiotic treatment regimens.将优化算法应用于结核病抗生素治疗方案。
Cell Mol Bioeng. 2017 Dec;10(6):523-535. doi: 10.1007/s12195-017-0507-6. Epub 2017 Aug 30.
本文引用的文献
1
models of infection provide a route to new therapies.感染模型为新疗法提供了一条途径。
Drug Discov Today Dis Models. 2015 Spring;15:37-41. doi: 10.1016/j.ddmod.2014.02.006. Epub 2014 May 9.
2
Strategies for efficient numerical implementation of hybrid multi-scale agent-based models to describe biological systems.用于描述生物系统的混合多尺度基于智能体模型的高效数值实现策略。
Cell Mol Bioeng. 2015 Mar;8(1):119-136. doi: 10.1007/s12195-014-0363-6.
3
Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis.用于治疗结核病的利福平与异烟肼吸入制剂设计的系统药理学方法
CPT Pharmacometrics Syst Pharmacol. 2015 Mar;4(3):e00022. doi: 10.1002/psp4.22. Epub 2015 Mar 11.
4
Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling.通过基质辅助激光解吸电离质谱成像（MALDI-MSI）和连续液体微通道表面采样对左氧氟沙星在结核感染肺部病变中的分布进行质谱成像。
Int J Mass Spectrom. 2015 Feb 1;377:699-708. doi: 10.1016/j.ijms.2014.08.024.
5
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.计算模型预测，在结核分枝杆菌感染期间，白细胞介素-10通过平衡早期宿主免疫介导的抗菌反应与干酪样坏死来控制病灶杀菌。
J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734. Epub 2014 Dec 15.
6
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.一种整合宿主免疫与抗生素动力学以研究结核病治疗的计算工具。
J Theor Biol. 2015 Feb 21;367:166-179. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.
7
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.巨噬细胞极化在结核分枝杆菌感染期间驱动肉芽肿的转归。
Infect Immun. 2015 Jan;83(1):324-38. doi: 10.1128/IAI.02494-14. Epub 2014 Nov 3.
8
A model of isoniazid treatment of tuberculosis.异烟肼治疗结核病的模型。
J Theor Biol. 2014 Dec 21;363:367-73. doi: 10.1016/j.jtbi.2014.07.024. Epub 2014 Aug 2.
9
Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis.分析联合药物治疗，以制定缩短结核病治疗疗程的方案。
PLoS One. 2014 Jul 8;9(7):e101311. doi: 10.1371/journal.pone.0101311. eCollection 2014.
10
Tuberculosis vaccines--rethinking the current paradigm.结核病疫苗——重新思考当前模式。
Trends Immunol. 2014 Aug;35(8):387-95. doi: 10.1016/j.it.2014.04.006. Epub 2014 May 27.
Zotero 插件