Carriere Nicolas, Lopes Renaud, Defebvre Luc, Delmaire Christine, Dujardin Kathy
From the Université Lille Nord de France (N.C., R.L., L.D., C.D., K.D.), U1171, Lille; Service de Neurologie et Pathologie du Mouvement (N.C., L.D., K.D.) and Service de Neuroradiologie (R.L., C.D.), Centre Hospitalier Régional Universitaire, Lille, France.
Neurology. 2015 May 26;84(21):2116-23. doi: 10.1212/WNL.0000000000001619. Epub 2015 Apr 29.
To compare the striatum's resting-state functional connectivity in patients with Parkinson disease (PD) with and without impulse control disorders (ICDs).
Twenty patients with PD and ICDs, 19 patients with PD but no ICDs, and 19 healthy controls underwent fMRI in the resting state. The ventral striatum, dorsal caudate, and anterior and posterior putamen were segmented semiautomatically. For each region of interest, a seed-based connectivity analysis was performed on preprocessed fMRI data mapped on the ipsilateral cortical surface. An additional cortical thickness analysis was used to assess and compare gray matter atrophy in the 3 study subgroups.
The presence of an ICD in patients with PD was associated with functional disconnection between the left anterior putamen and both the left inferior temporal gyrus and the left anterior cingulate gyrus, as well as a trend toward a functional disconnection between several motor and associative striatal regions and limbic, associative, and motor cortical regions. Patients without ICDs did not differ from healthy controls in corticostriatal connectivity. The cortical thickness analysis did not reveal any significant differences among the 3 study subgroups.
In PD, ICDs are associated with altered connectivity between an associative striatal area (the left anterior putamen) and associative and limbic cortical regions (the left inferior temporal gyrus and the left anterior cingulate gyrus).
比较帕金森病（PD）伴与不伴冲动控制障碍（ICD）患者纹状体的静息态功能连接。
20例伴ICD的PD患者、19例不伴ICD的PD患者和19名健康对照者接受静息态功能磁共振成像（fMRI）检查。对腹侧纹状体、背侧尾状核以及壳核的前、后部进行半自动分割。对于每个感兴趣区域，在映射于同侧皮质表面的预处理fMRI数据上进行基于种子点的连接性分析。另外采用皮质厚度分析来评估和比较3个研究亚组中的灰质萎缩情况。
PD患者中ICD的存在与左侧壳核前部与左侧颞下回及左侧前扣带回之间的功能断开有关，并且在几个运动和联合纹状体区域与边缘、联合及运动皮质区域之间存在功能断开的趋势。不伴ICD的患者在皮质-纹状体连接性方面与健康对照者无差异。皮质厚度分析未显示3个研究亚组之间存在任何显著差异。
在PD中，ICD与联合纹状体区域（左侧壳核前部）与联合及边缘皮质区域（左侧颞下回和左侧前扣带回）之间连接性改变有关。
