Premi E, Pilotto A, Garibotto V, Bigni B, Turrone R, Alberici A, Cottini E, Poli L, Bianchi M, Formenti A, Cosseddu M, Gazzina S, Magoni M, Bertoli M, Paghera B, Borroni B, Padovani A
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Stroke Unit, Azienda Ospedaliera "Spedali Civili", Spedali Civili Hospital, Brescia, Italy.
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany.
Parkinsonism Relat Disord. 2016 Sep;30:62-6. doi: 10.1016/j.parkreldis.2016.05.028. Epub 2016 May 27.
Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas.
84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM).
PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+.
the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub.
帕金森病（PD）中的冲动控制障碍症状（ICD）最近通过磁共振成像与皮质 - 纹状体连接受损相关，特别是在左侧壳核与额叶联合区域之间。
84名患者进入研究（21名PD - ICD +和64名PD - ICD -）并接受DATSCAN成像。使用BRASS软件（瑞典赫耳墨斯）评估纹状体示踪剂摄取。采用统计参数映射（SPM）进行全脑分析。
与PD - ICD -相比，PD - ICD +显示左侧壳核和左侧额下回示踪剂摄取显著减少。以左侧壳核为种子点的功能协方差分析表明，与ICD -患者相比，ICD +患者与对侧基底神经节和同侧扣带回皮质没有功能协方差，这是PD - ICD +中半球间和半球内多巴胺结合受损的指标。
结果支持并扩展了通过以左侧基底神经节为中心枢纽的不对称分子额纹状体网络破坏与PD患者ICD症状相关的功能断开综合征的概念。
