Kanitakis J, Zambruno G, Viac J, Tommaselli L, Thivolet J
INSERM U209, Clinique Dermatologique, Hôp. Ed. Herriot, Lyon, France.
J Cutan Pathol. 1989 Oct;16(5):272-6. doi: 10.1111/j.1600-0560.1989.tb00051.x.
p29 is a cytoplasmic serine phosphoprotein of 29 kD MW, closely linked to estrogen receptors. In this work we studied the expression of p29 protein in normal human skin and a group of cutaneous benign and malignant tumors by using a monoclonal antibody (ERD5) that specifically recognizes p29. In normal skin, p29 reactivity was observed in epidermal and some adnexal keratinocytes, as well as in smooth muscle cells of dermal arterioles and arrector pili muscles. p29 was also detected in most, but not all, epithelial tumors studied. The expression of p29 was generally stronger in the more differentiated (keratinized) normal and neoplastic keratinocytes; however, no correlation could be noted between immunochemical staining for p29 and either benignity of the lesion or sex of the patient considered. Whereas, in breast cancer, the expression of p29 is reported to correlate with endocrine response, the precise relationship between epithelial tumors of the skin and the action of estrogens remains to be elucidated.
p29是一种分子量为29kD的细胞质丝氨酸磷蛋白，与雌激素受体密切相关。在本研究中，我们使用一种特异性识别p29的单克隆抗体（ERD5），研究了p29蛋白在正常人体皮肤以及一组皮肤良性和恶性肿瘤中的表达情况。在正常皮肤中，在表皮和一些附属器角质形成细胞以及真皮小动脉和立毛肌的平滑肌细胞中观察到p29反应性。在大多数（但不是全部）所研究的上皮性肿瘤中也检测到了p29。p29在分化程度较高（角化）的正常和肿瘤性角质形成细胞中的表达通常更强；然而，p29的免疫化学染色与病变的良性程度或所考虑患者的性别之间均未发现相关性。虽然在乳腺癌中，p29的表达据报道与内分泌反应相关，但皮肤上皮性肿瘤与雌激素作用之间的确切关系仍有待阐明。
