Cano A, Rivera J, Parrilla J J, Abad L
Departamento de Obstetricia y Ginecología, Facultad de Medicina, Espinardo, Murcia, Spain.
Gynecol Obstet Invest. 1988;26(2):166-70. doi: 10.1159/000293689.
The concentration of P29, a phosphoprotein related to estradiol receptor (RE), was measured by an immunoradiometric assay in human breast cancer cytosol and the results compared with the levels of RE and progesterone receptors (RP), as measured by the classical ligand-binding assay. Good linear correlation was found between P29 and RE, but not RP. Tumors which were positive for both RE and RP had a higher P29 mean value than RE-negative, RP-negative tumors. Menopausal status of the patients influenced the result, since premenopausal women had lower mean concentrations or were P29-positive less frequently than postmenopausal women. RE-negative, RP-positive tumors tended to have positive P29 levels. The correlation between RE and P29 corroborates results obtained with other techniques and supports a role for P29 in predicting response to hormonal treatment.
采用免疫放射分析测定了人乳腺癌细胞溶质中与雌二醇受体（RE）相关的磷蛋白P29的浓度，并将结果与通过经典配体结合分析测定的RE和孕酮受体（RP）水平进行了比较。发现P29与RE之间存在良好的线性相关性，但与RP之间不存在。RE和RP均为阳性的肿瘤的P29平均值高于RE阴性、RP阴性的肿瘤。患者的绝经状态影响结果，因为绝经前女性的平均浓度较低或P29阳性的频率低于绝经后女性。RE阴性、RP阳性的肿瘤往往具有阳性的P29水平。RE与P29之间的相关性证实了用其他技术获得的结果，并支持P29在预测激素治疗反应中的作用。
