脂肪乳剂在胃内的稳定性和液滴大小会调节年轻人的胃肠道反应及随后的食物摄入量。
Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults.
作者信息
Hussein Mahamoud O, Hoad Caroline L, Wright Jeff, Singh Gulzar, Stephenson Mary C, Cox Eleanor F, Placidi Elisa, Pritchard Susan E, Costigan Carolyn, Ribeiro Henelyta, Ciampi Elisabetta, Nandi Asish, Hedges Nick, Sanderson Paul, Peters Harry P F, Rayment Pip, Spiller Robin C, Gowland Penny A, Marciani Luca
机构信息
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, and.
Gastrointestinal Surgery, University of Nottingham, Nottingham, United Kingdom;
出版信息
J Nutr. 2015 Jun;145(6):1170-7. doi: 10.3945/jn.114.204339. Epub 2015 Apr 29.
BACKGROUND
Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses.
OBJECTIVES
We tested the hypotheses that gastrointestinal physiologic responses and satiety will be increased by an increase in intragastric stability and by a decrease in fat droplet size of a fat emulsion.
METHODS
This was a double-blind, randomized crossover study in 11 healthy persons [8 men and 3 women, aged 24 ± 1 y; body mass index (in kg/m(2)): 24.4 ± 0.9] who consumed meals containing 300-g 20% oil and water emulsion (2220 kJ) with 1) larger, 6-μm mean droplet size (Coarse treatment) expected to cream in the stomach; 2) larger, 6-μm mean droplet size with 0.5% locust bean gum (LBG; Coarse+LBG treatment) to prevent creaming; or 3) smaller, 0.4-μm mean droplet size with LBG (Fine+LBG treatment). The participants were imaged hourly by using MRI and food intake was assessed by using a meal that participants consumed ad libitum.
RESULTS
The Coarse+LBG treatment (preventing creaming in the stomach) slowed gastric emptying, resulting in 12% higher gastric volume over time (P < 0.001), increased small bowel water content (SBWC) by 11% (P < 0.01), slowed appearance of the (13)C label in the breath by 17% (P < 0.01), and reduced food intake by 9% (P < 0.05) compared with the Coarse treatment. The Fine+LBG treatment (smaller droplet size) slowed gastric emptying, resulting in 18% higher gastric volume (P < 0.001), increased SBWC content by 15% (P < 0.01), and significantly reduced food intake by 11% (P < 0.05, equivalent to an average of 411 kJ less energy consumed) compared with the Coarse+LBG treatment. These high-fat meals stimulated substantial increases in SBWC, which increased to a peak at 4 h at 568 mL (range: 150-854 mL; P < 0.01) for the Fine+LBG treatment.
CONCLUSION
Manipulating intragastric stability and fat emulsion droplet size can influence human gastrointestinal physiology and food intake.
背景
脂肪乳剂的胃内乳析和液滴大小可能会影响胃内行为以及胃肠道和饱腹感反应。
目的
我们检验了以下假设，即胃内稳定性增加和脂肪乳剂脂肪液滴大小减小会增强胃肠道生理反应和饱腹感。
方法
这是一项针对11名健康人的双盲、随机交叉研究[8名男性和3名女性，年龄24±1岁；体重指数（kg/m²）：24.4±0.9]，他们食用含有300克20%油和水乳剂（2220千焦）的餐食，其中1）平均液滴大小为6微米（粗颗粒组），预计在胃内会发生乳析；2）平均液滴大小为6微米并添加0.5%刺槐豆胶（LBG；粗颗粒+LBG组）以防止乳析；或3）平均液滴大小为0.4微米并添加LBG（细颗粒+LBG组）。每小时使用MRI对参与者进行成像，并通过参与者随意食用的餐食评估食物摄入量。
结果
粗颗粒+LBG组（防止胃内乳析）使胃排空减慢，导致胃容积随时间增加12%（P<0.001），小肠含水量（SBWC）增加11%（P<0.01），呼出气体中¹³C标记物的出现减慢17%（P<0.01），与粗颗粒组相比，食物摄入量减少9%（P<0.05）。细颗粒+LBG组（较小液滴大小）使胃排空减慢，导致胃容积增加18%（P<0.001），SBWC含量增加15%（P<0.01），与粗颗粒+LBG组相比，食物摄入量显著减少11%（P<0.05，相当于平均少摄入411千焦能量）。这些高脂餐食使SBWC大幅增加，细颗粒+LBG组在4小时时增加至峰值568毫升（范围：150 - 854毫升；P<0.01）。
结论
控制胃内稳定性和脂肪乳剂液滴大小可影响人体胃肠道生理功能和食物摄入量。
Zotero 插件